Jansen S W, Akintola A A, Roelfsema F, van der Spoel E, Cobbaert C M, Ballieux B E, Egri P, Kvarta-Papp Z, Gereben B, Fekete C, Slagboom P E, van der Grond J, Demeneix B A, Pijl H, Westendorp R G J, van Heemst D
Department of Gerontology and Geriatrics, Leiden University Medical Centre, Leiden, The Netherlands.
Department of Medicine, Section Endocrinology, Leiden University Medical Centre, Leiden, The Netherlands.
Sci Rep. 2015 Jun 19;5:11525. doi: 10.1038/srep11525.
Few studies have included subjects with the propensity to reach old age in good health, with the aim to disentangle mechanisms contributing to staying healthier for longer. The hypothalamic-pituitary-thyroid (HPT) axis maintains circulating levels of thyroid stimulating hormone (TSH) and thyroid hormone (TH) in an inverse relationship. Greater longevity has been associated with higher TSH and lower TH levels, but mechanisms underlying TSH/TH differences and longevity remain unknown. The HPT axis plays a pivotal role in growth, development and energy metabolism. We report that offspring of nonagenarians with at least one nonagenarian sibling have increased TSH secretion but similar bioactivity of TSH and similar TH levels compared to controls. Healthy offspring and spousal controls had similar resting metabolic rate and core body temperature. We propose that pleiotropic effects of the HPT axis may favour longevity without altering energy metabolism.
很少有研究纳入有健康长寿倾向的受试者，目的是厘清有助于更长久保持健康的机制。下丘脑 - 垂体 - 甲状腺（HPT）轴维持促甲状腺激素（TSH）和甲状腺激素（TH）的循环水平呈反比关系。更长的寿命与较高的TSH水平和较低的TH水平相关，但TSH/TH差异与长寿背后的机制仍不清楚。HPT轴在生长、发育和能量代谢中起关键作用。我们报告称，与对照组相比，有至少一个百岁兄弟姐妹的百岁老人的后代TSH分泌增加，但TSH的生物活性相似且TH水平相似。健康的后代和配偶对照组的静息代谢率和核心体温相似。我们提出，HPT轴的多效性作用可能有利于长寿而不改变能量代谢。
