Department of Microbiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Research Institute for Internal Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway.
Department of Microbiology, Oslo University Hospital, Rikshospitalet, Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.
Clin Microbiol Infect. 2015 Oct;21(10):938-45. doi: 10.1016/j.cmi.2015.06.008. Epub 2015 Jun 18.
Several studies have reported an increased incidence of candidaemia and a redistribution of species, with a decrease in the number of Candida albicans isolates. In Norway, a prospective, national surveillance study of candidaemia has been ongoing since 1991. Data from the period 1991-2003 have been published previously. The aim of this study was to follow up the incidence, species distribution and antifungal susceptibility of Candida species isolates from blood cultures in the period 2004-2012, and compare them with the corresponding findings from the period 1991-2003. Blood culture isolates of Candida species from all medical microbiological laboratories in Norway were identified and susceptibility tested at the Norwegian Mycological Reference Laboratory. A total of 1724 isolates were recovered from 1653 patients in the period 2004-2012. Comparison of the two periods showed that the average incidence of candidaemia episodes per 100 000 inhabitants increased from 2.4 (1991-2003) to 3.9 (2004-2012). The increase in incidence in the latter period was significantly higher in patients aged >40 years (p 0.001), and a marked increase was observed in patients aged >60 years (p < 0.001). In conclusion, the average incidence in Norway over a period of 22 years modestly increased from 2.4 to 3.9 per 100,000 inhabitants, this being mainly accounted for by candidaemia in the elderly. The species distribution was stable, and the rate of acquired resistance was low.
多项研究报告称，白色念珠菌的分离株数量减少，同时念珠菌血症的发病率增加，且菌种分布发生了变化。在挪威，自 1991 年以来一直在进行一项针对念珠菌血症的前瞻性全国监测研究。此前已经公布了 1991-2003 年的数据。本研究旨在跟踪 2004-2012 年血液培养中念珠菌属分离株的发病率、菌种分布和抗真菌药物敏感性，并与 1991-2003 年的相应发现进行比较。挪威所有医学微生物学实验室的血液培养念珠菌属分离株均在挪威真菌学参考实验室进行鉴定和药敏试验。在 2004-2012 年期间，从 1653 名患者中分离出 1724 株念珠菌属分离株。两个时期的比较表明，每 10 万人中念珠菌血症的平均发病率从 2.4（1991-2003）增加到 3.9（2004-2012）。在后者期间，40 岁以上患者的发病率增加显著更高（p<0.001），60 岁以上患者的发病率明显增加（p<0.001）。总之，在 22 年的时间里，挪威的平均发病率从每 10 万人 2.4 略微增加到 3.9，这主要归因于老年人的念珠菌血症。菌种分布稳定，获得性耐药率低。
