de Aquino Maria Teresa P, Malhotra Anshu, Mishra Manoj K, Shanker Anil
Department of Biochemistry and Cancer Biology, School of Medicine, Meharry Medical College, Nashville, TN 37208, USA.
Department of Biological Sciences, Alabama State University, Montgomery, AL 36101, USA.
Immunol Lett. 2015 Aug;166(2):117-33. doi: 10.1016/j.imlet.2015.05.018. Epub 2015 Jun 19.
Since the formulation of the tumour immunosurveillance theory, considerable focus has been on enhancing the effectiveness of host antitumour immunity, particularly with respect to T cells. A cancer evades or alters the host immune response by various ways to ensure its development and survival. These include modifications of the immune cell metabolism and T cell signalling. An inhibitory cytokine milieu in the tumour microenvironment also leads to immune suppression and tumour progression within a host. This review traces the development in the field and attempts to summarize the hurdles that the approach of adoptive T cell immunotherapy against cancer faces, and discusses the conditions that must be improved to allow effective eradication of cancer.
自肿瘤免疫监视理论形成以来，相当多的研究重点都放在了增强宿主抗肿瘤免疫的有效性上，尤其是针对T细胞。癌症通过多种方式逃避或改变宿主免疫反应，以确保其发展和存活。这些方式包括免疫细胞代谢和T细胞信号传导的改变。肿瘤微环境中的抑制性细胞因子环境也会导致宿主内的免疫抑制和肿瘤进展。本综述追溯了该领域的发展，并试图总结过继性T细胞免疫疗法治疗癌症所面临的障碍，并讨论为有效根除癌症必须改善的条件。
