圣罗勒根提取物抗炎、镇痛和解热活性的药理和植物化学评价。
Pharmacological and phytochemical evaluation of Ocimum sanctum root extracts for its antiinflammatory, analgesic and antipyretic activities.
作者信息
Kumar Anant, Agarwal Karishma, Maurya Anil Kumar, Shanker Karuna, Bushra Umme, Tandon Sudeep, Bawankule Dnyaneshwar U
机构信息
Department of Molecular Bioprospection, Biotechnology Division, Central Institute of Medicinal and Aromatic Plants, Lucknow, Uttar Pradesh, India.
Department of Process Chemistry and Technology, Central Institute of Medicinal and Aromatic Plants, Lucknow, Uttar Pradesh, India.
出版信息
Pharmacogn Mag. 2015 May;11(Suppl 1):S217-24. doi: 10.4103/0973-1296.157743.
BACKGROUND
Long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs) increases risk of having a range of gastrointestinal problems. Therefore, new anti-inflammatory, analgesic, antipyretic drugs having lesser side effects are being searched all overthe world as alternatives to NSAIDs.
AIMS
To evaluate the anti-inflammatory, analgesic and antipyretic profile of Ocimum sanctum root extracts.
MATERIALS AND METHODS
Anti-inflammatory profile of hexane (STH), chloroform (STC), ethyl acetate (STE), butanol (STB) and water (STW) extracts of OS was carried out by using carrageenan induced paw edema. STE a most active extract was further validated in dose dependent manner for anti-inflammatory, analgesic and antipyretic activity as well as oral toxicity profile in small laboratory animals. Identification of bioactives flux and chemical signature of most active fraction STE was developed by using the high-performance liquid chromatography fingerprinting.
RESULTS
An ethyl acetate fraction (STE) exhibit most potent anti-inflammatory activity followed by STB, STW, STC and STH. Dose response study of STE showed anti-inflammatory, analgesic and anti-pyretic potential in dose-dependent manner without any toxic effect at dose 2000 mg/kg. Chemical fingerprint revealed the presence of flavanoids.
CONCLUSIONS
The present research revealed that STE possess anti-inflammatory, analgesic and anti-pyretic properties. However, future research is advocated to evaluate the pharmacological properties of isolated bioactive compounds.
背景
长期使用非甾体抗炎药（NSAIDs）会增加出现一系列胃肠道问题的风险。因此，全世界都在寻找副作用较小的新型抗炎、镇痛、解热药物，以替代NSAIDs。
目的
评估神圣罗勒根提取物的抗炎、镇痛和解热特性。
材料与方法
通过角叉菜胶诱导的爪肿胀实验，对神圣罗勒的己烷提取物（STH）、氯仿提取物（STC）、乙酸乙酯提取物（STE）、丁醇提取物（STB）和水提取物（STW）进行抗炎特性研究。作为最具活性的提取物，STE进一步以剂量依赖方式在小型实验动物中验证其抗炎、镇痛和解热活性以及口服毒性。利用高效液相色谱指纹图谱技术，对最具活性组分STE的生物活性通量和化学特征进行鉴定。
结果
乙酸乙酯组分（STE）表现出最强的抗炎活性，其次是STB、STW、STC和STH。STE的剂量反应研究表明，其具有剂量依赖性的抗炎、镇痛和解热潜力，在2000mg/kg剂量下无任何毒性作用。化学指纹图谱显示存在黄酮类化合物。
结论
本研究表明STE具有抗炎、镇痛和解热特性。然而，提倡未来开展研究以评估分离出的生物活性化合物的药理特性。
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