Department of Pharmaceutics, Jayawantrao Sawant College of Pharmacy and Research, Savitribai Phule Pune University, Pune, 411028, India.
School of Health Science and Technology, Dr Vishwanath Karad MIT World Peace University, Pune, Maharashtra, India.
Recent Adv Drug Deliv Formul. 2024;18(2):100-109. doi: 10.2174/0126673878281000240411073412.
In recent times, technological and scientific advances have been made in studying and developing orally delivered medication. Such studies demonstrate the importance of the oral route among patients. The accuracy of drug delivery is very important to achieve a successful therapeutic effect in the case of various pharmaceutical products. A novel drug delivery system adds new benefits or advantages to a drug. This review covers all the aspects of medicated chewing gum (MCG) as a new drug delivery method, including the benefits and drawbacks, manufacturing methods, type of MCG, composition of chewing gum, evaluation parameters, factors that affected the release of API, its pharmaceutical significance, various marketed chewing gum and chewing gum packaging. Chewing gum as a drug delivery system has the potential to cure or prevent various indications, such as analgesic, CNS stimulation, smoking cessation, motion sickness, and treatment and prevention of dental caries or gingivitis. Pharmaceutical distribution to the oral mucosa can be made more convenient and enticing with the help of MCG. Compared to conventional techniques, this delivery system has a longer-lasting effect, which makes it a viable option for treating digestive problems, headaches, migraines, coughing, anxiety, and allergies.
近年来，在研究和开发口服药物方面取得了技术和科学上的进步。这些研究表明，口服途径在患者中非常重要。在各种药物产品中，药物输送的准确性对于达到成功的治疗效果非常重要。新型药物输送系统为药物增加了新的益处或优势。本综述涵盖了药用口香糖（MCG）作为一种新的药物输送方法的所有方面，包括优点和缺点、制造方法、MCG 的类型、口香糖的组成、评价参数、影响 API 释放的因素、其在药物方面的意义、各种市售口香糖和口香糖包装。作为药物输送系统的口香糖有可能治愈或预防各种适应症，如镇痛药、CNS 刺激、戒烟、晕车、以及治疗和预防龋齿或牙龈炎。在 MCG 的帮助下，可以更方便、更有吸引力地将药物分配到口腔黏膜上。与传统技术相比，这种输送系统的效果持续时间更长，因此是治疗消化问题、头痛、偏头痛、咳嗽、焦虑和过敏等问题的可行选择。
