Papageorgiou Valia, Vargiami Euthymia, Kontopoulos Eleutherios, Kardaras Panagiotis, Economou Marina, Athanassiou-Mataxa Miranta, Kirkham Fenella, Zafeiriou Dimitrios I
1st Department of Pediatrics, Aristotle University of Thessaloniki, Hippokratio General Hospital, Thessaloniki, Greece.
3rd Department of Pediatrics, Aristotle University of Thessaloniki, Hippokratio General Hospital, Thessaloniki, Greece.
Eur J Paediatr Neurol. 2015 Sep;19(5):591-6. doi: 10.1016/j.ejpn.2015.05.009. Epub 2015 Jun 12.
The relationship between iron status and febrile seizures has been examined in various settings, mainly in the Developing World, with conflicting results. The aim of this study was to investigate any association between iron deficiency and febrile seizures (FS) in European children aged 6-60 months.
Prospective, case-control study.
Greek population in Thessaloniki.
50 patients with febrile seizures (cases) and 50 controls (children presenting with fever, without seizures).
None.
Haematologic parameters (haemoglobin concentration, haematocrit, mean corpuscular volume, red cell distribution width), plasma iron, total iron-binding capacity, plasma ferritin, transferrin saturation and soluble transferrin receptors were compared in cases and controls.
Plasma ferritin was lower (median [range]: 42.8 (3-285.7) vs 58.3 (21.4-195.3 ng/ml; p = 0.02) and Total Iron Binding Capacity (TIBC) higher (mean [Standard Deviation] 267 [58.9] vs 243 [58.45] μg/dl, p = 0.04) in cases than in controls. Results were similar for 12 complex FS cases (ferritin 30 (3-121 vs 89 (41.8-141.5ng/lL; TIBC 292.92 [68.0] vs 232.08 [36.27] μg/dL). Iron deficiency, defined as ferritin <30 ng/ml, was more frequent in cases (24%) than controls (4%; p = 0.004). Ferritin was lower and TIBC higher in 18 with previous seizures than in 32 with a first seizure although haemoglobin and mean cell haemoglobin concentration were higher.
European children with febrile seizures have lower Ferritin than those with fever alone, and iron deficiency, but not anaemia, is associated with recurrence. Iron status screening should be considered as routine for children presenting with or at high risk for febrile seizures.
铁状态与热性惊厥之间的关系已在各种环境中进行了研究，主要是在发展中世界，结果相互矛盾。本研究的目的是调查6至60个月大的欧洲儿童缺铁与热性惊厥（FS）之间的任何关联。
前瞻性病例对照研究。
塞萨洛尼基的希腊人群。
50例热性惊厥患者（病例）和50名对照（发热但无惊厥的儿童）。
无。
比较病例组和对照组的血液学参数（血红蛋白浓度、血细胞比容、平均红细胞体积、红细胞分布宽度）、血浆铁、总铁结合力、血浆铁蛋白、转铁蛋白饱和度和可溶性转铁蛋白受体。
病例组的血浆铁蛋白较低（中位数[范围]：42.8（3 - 285.7）对58.3（21.4 - 195.3 ng/ml；p = 0.02），总铁结合力（TIBC）较高（均值[标准差]267 [58.9]对243 [58.45] μg/dl，p = 0.04）。12例复杂性FS病例的结果相似（铁蛋白30（3 - 121对89（41.8 - 141.5ng/lL；TIBC 292.92 [68.0]对232.08 [36.27] μg/dL）。定义为铁蛋白<30 ng/ml的缺铁在病例组（24%）中比对照组（4%）更常见（p = 0.004）。18例有既往惊厥史的患儿铁蛋白较低，TIBC较高，而32例首次惊厥的患儿血红蛋白和平均红细胞血红蛋白浓度较高。
患有热性惊厥的欧洲儿童的铁蛋白低于单纯发热的儿童，缺铁而非贫血与复发有关。对于出现热性惊厥或有热性惊厥高风险的儿童，应考虑将铁状态筛查作为常规检查。
