西西里岛火山地区的几种特定部位癌症发病率有所上升。
Several Site-specific Cancers are Increased in the Volcanic Area in Sicily.
作者信息
Russo Marco, Malandrino Pasqualino, Addario Walter Pollina, Dardanoni Gabriella, Vigneri Paolo, Pellegriti Gabriella, Squatrito Sebastiano, Vigneri Riccardo
机构信息
Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Medical Center, Catania, Italy
Endocrinology, Department of Clinical and Experimental Medicine, University of Catania, Garibaldi-Nesima Medical Center, Catania, Italy.
出版信息
Anticancer Res. 2015 Jul;35(7):3995-4001.
BACKGROUND
Worldwide, thyroid cancer incidence is increased in many volcanic areas. Whether the incidence of other types of cancers are also increased is not known.
MATERIALS AND METHODS
We analyzed cancer registries covering 82% of the population of Sicily to compare the incidence of 34 site-specific types of cancer in area around the volcano Mt. Etna (where thyroid cancer is very high) with adjacent non-volcanic areas. Differences in crude incidence rate ratios (IRR) between the two areas were calculated.
RESULTS
Considering 72,197 incident cases, thyroid cancer (IRR=1.68 in females and 1.40 in males) and lymphatic leukemia (IRR: females=1.48, males=1.39) were significantly increased in the volcanic area in both men and women. Hodgkin's lymphoma, stomach and breast cancer in women and prostate cancer in men were also significantly increased in the volcanic area.
CONCLUSION
Several, but not all types of cancers are significantly increased in the volcanic area of Sicily, indicating that an active volcanic environment may be a risk factor for cancer other than thyroid cancer.
背景
在全球范围内，许多火山地区的甲状腺癌发病率都有所上升。其他类型癌症的发病率是否也会上升尚不清楚。
材料与方法
我们分析了覆盖西西里岛82%人口的癌症登记数据，以比较埃特纳火山周边地区（甲状腺癌发病率非常高）与相邻非火山地区34种特定部位癌症的发病率。计算了两个地区粗发病率比（IRR）的差异。
结果
在考虑的72197例发病病例中，火山地区的男性和女性甲状腺癌（女性IRR = 1.68，男性IRR = 1.40）以及淋巴白血病（女性IRR = 1.48，男性IRR = 1.39）均显著增加。火山地区女性的霍奇金淋巴瘤、胃癌和乳腺癌以及男性的前列腺癌也显著增加。
结论
西西里岛的火山地区有几种（但并非所有）癌症类型显著增加，这表明活跃的火山环境可能是除甲状腺癌之外的癌症风险因素。
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