来自褐藻膜网藻的具有抗炎活性的二硫化物。

Disulfides with Anti-inflammatory Activity from the Brown Alga Dictyopteris membranacea.

作者信息

Dimou Maria, Ioannou Efstathia, Daskalaki Maria G, Tziveleka Leto A, Kampranis Sotirios C, Roussis Vassilios

机构信息

Department of Pharmacognosy and Chemistry of Natural Products, Faculty of Pharmacy, School of Health Sciences, University of Athens , Panepistimiopolis Zografou, Athens 15771, Greece.

Department of Biochemistry, School of Medicine, University of Crete , P.O. Box 2208, Heraklion 71003, Greece.

出版信息

J Nat Prod. 2016 Mar 25;79(3):584-9. doi: 10.1021/acs.jnatprod.5b01031. Epub 2016 Mar 4.

DOI:10.1021/acs.jnatprod.5b01031

PMID:26943727

Abstract

Six new (1, 2, and 4-7) and two previously reported (3 and 8) disulfides, along with 4-butyl-2,6-cycloheptadienone, γ-tocopherol, and δ-tocopherol, were isolated from an organic extract of the brown alga Dictyopteris membranacea, collected at Gerolimenas Bay, Greece. The structure elucidation of the isolated natural products was based on analysis of their spectroscopic data. Compounds 1, 3-6, and 8 were evaluated for their antibacterial and anti-inflammatory activities. None of the compounds displayed antibacterial activity against two resistant strains of Staphylococcus aureus and one strain of Escherichia coli. In contrast, metabolite 5 was able to cause strong inhibition of NO production with an IC50 value of 3.8 μM using an LPS stimulation assay.

摘要

从采集于希腊杰罗利梅纳斯湾的褐藻膜质网地藻的有机提取物中，分离出六种新的二硫化物（1、2、4 - 7）和两种先前报道的二硫化物（3和8），以及4 - 丁基 - 2,6 - 环庚二烯酮、γ - 生育酚和δ - 生育酚。对分离出的天然产物的结构解析基于对其光谱数据的分析。对化合物1、3 - 6和8进行了抗菌和抗炎活性评估。这些化合物对两种耐甲氧西林金黄色葡萄球菌菌株和一种大肠杆菌菌株均未表现出抗菌活性。相比之下，在脂多糖刺激试验中，代谢物5能够强烈抑制一氧化氮的产生，IC50值为3.8 μM。