Inagaki Y, Horiuchi S, Une T, Nakaya R
Department of Microbiology, School of Medicine, Tokyo Medical and Dental University, Japan.
J Antimicrob Chemother. 1989 Oct;24(4):547-9. doi: 10.1093/jac/24.4.547.
The in-vitro activity of DR-3355, the S-(-)-isomer of ofloxacin, was determined against bacterial pathogens associated with travellers' diarrhoea. DR-3355 was highly active against isolates of enteropathogenic Escherichia coli (MIC90 0.05 mg/l), Salmonella spp. (MIC90 0.10 mg/l), Shigella spp. (MIC90 0.10 mg/l), Campylobacter jejuni (MIC90 0.39 mg/l) and Vibrio parahaemolyticus (MIC90 0.39 mg/l). The activity of DR-3355 against these bacteria was generally two- to eight-fold greater than that of ofloxacin and equal to, or only two-fold less than, that of ciprofloxacin with the exception of isolates of C. jejuni, which were two-fold less susceptible to ciprofloxacin than to DR-3355.
测定了氧氟沙星的S-(-)-异构体DR-3355对与旅行者腹泻相关的细菌病原体的体外活性。DR-3355对肠道致病性大肠杆菌分离株（MIC90为0.05mg/L）、沙门氏菌属（MIC90为0.10mg/L）、志贺氏菌属（MIC90为0.10mg/L）、空肠弯曲菌（MIC90为0.39mg/L）和副溶血性弧菌（MIC90为0.39mg/L）具有高度活性。DR-3355对这些细菌的活性通常比对氧氟沙星高2至8倍，除空肠弯曲菌分离株外，与环丙沙星的活性相当或仅低2倍，空肠弯曲菌分离株对环丙沙星的敏感性比对DR-3355低2倍。
