阿昔洛韦预防可降低HIV感染者带状疱疹的发病率：一项随机临床试验的结果
Acyclovir Prophylaxis Reduces the Incidence of Herpes Zoster Among HIV-Infected Individuals: Results of a Randomized Clinical Trial.
作者信息
Barnabas Ruanne V, Baeten Jared M, Lingappa Jairam R, Thomas Katherine K, Hughes James P, Mugo Nelly R, Delany-Moretlwe Sinead, Gray Glenda, Rees Helen, Mujugira Andrew, Ronald Allan, Stevens Wendy, Kapiga Saidi, Wald Anna, Celum Connie
机构信息
Department of Global Health, University of Washington Department of Medicine, University of Washington Department of Epidemiology, University of Washington Vaccine and Infectious Diseases Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Department of Global Health, University of Washington Department of Medicine, University of Washington Department of Epidemiology, University of Washington.
出版信息
J Infect Dis. 2016 Feb 15;213(4):551-5. doi: 10.1093/infdis/jiv318. Epub 2015 Jun 8.
Abstract
Human immunodeficiency virus (HIV)-infected persons have higher rates of herpes zoster than HIV-uninfected individuals. We assessed whether twice daily treatment with 400 mg of oral acyclovir reduces the incidence of herpes zoster in a randomized, double-blind, placebo-controlled trial among 3408 persons coinfected with HIV and herpes simplex virus type 2. During 5175 person-years of follow-up, 26 cases of herpes zoster occurred among those assigned acyclovir, compared with 69 cases among those assigned placebo (rates, 1.00 and 2.68/100 person-years, respectively), a relative decrease of 62% (hazard ratio, 0.38; 95% confidence interval, .24-.67; P < .001). Daily acyclovir prophylaxis significantly reduced herpes zoster incidence among HIV-infected persons.
摘要
感染人类免疫缺陷病毒（HIV）的人群患带状疱疹的几率高于未感染HIV的个体。在一项针对3408名同时感染HIV和2型单纯疱疹病毒的患者的随机、双盲、安慰剂对照试验中，我们评估了每日两次服用400毫克口服阿昔洛韦是否能降低带状疱疹的发病率。在5175人年的随访期间，接受阿昔洛韦治疗的患者中有26例发生带状疱疹，而接受安慰剂治疗的患者中有69例（发病率分别为1.00和2.68/100人年），相对降低了62%（风险比，0.38；95%置信区间，0.24 - 0.67；P < 0.001）。每日服用阿昔洛韦进行预防可显著降低HIV感染者带状疱疹的发病率。
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