Sallee Floyd R
Department of Psychiatry & Behavioral Neuroscience, University of Cincinnati College of Medicine , Cincinnati, Ohio.
J Child Adolesc Psychopharmacol. 2015 Sep;25(7):558-65. doi: 10.1089/cap.2014.0160. Epub 2015 Jul 7.
The purpose of this study was to examine the temporal occurrence and severity of inadequate attention-deficit/hyperactivity disorder (ADHD) symptom control throughout the day, and, more specifically, the frequency and severity of associated functional impairments and their apparent emotional impact on parents and caregivers during the early morning routine before school, in children and adolescents with ADHD currently treated with stable doses of stimulant medications.
Information was obtained from 201 primary caregivers of children and adolescents with ADHD using a self-administered, on-line quantitative research survey.
Inadequately controlled ADHD symptoms were rated as most severe during the evening homework time and the early morning routine. The majority of caregivers reported early morning ADHD symptoms and impairment of early morning functioning (EMF) as moderate to severe. Caregiver reactions to their child's early morning ADHD symptoms and unwanted behaviors included feeling overwhelmed, exhausted, and constantly stressed.
Control of EMF impairments from inadequately controlled ADHD symptoms is a significant unmet need in children and adolescents with ADHD treated with stable morning doses of stimulant medications. Current orally administered stimulant treatment options have not addressed this challenge.
本研究旨在探讨全天注意力缺陷多动障碍(ADHD)症状控制不足的时间发生情况及严重程度,更具体地说,是探讨目前接受稳定剂量兴奋剂药物治疗的ADHD儿童和青少年在上学前清晨日常活动中相关功能损害的频率和严重程度,以及这些损害对父母和照顾者明显的情绪影响。
通过自我管理的在线定量研究调查,从201名ADHD儿童和青少年的主要照顾者处获取信息。
ADHD症状控制不足在晚上做作业时间和清晨日常活动期间被评为最严重。大多数照顾者报告清晨ADHD症状和清晨功能损害(EMF)为中度至重度。照顾者对其孩子清晨ADHD症状和不良行为的反应包括感到不堪重负、疲惫不堪和持续紧张。
对于接受稳定晨间剂量兴奋剂药物治疗的ADHD儿童和青少年,控制因ADHD症状控制不足导致的EMF损害是一项尚未得到满足的重大需求。目前口服兴奋剂治疗方案尚未应对这一挑战。