• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

与对照组相比,接受兴奋剂治疗的注意力缺陷/多动障碍儿童的清晨功能损害:对家庭的影响。

Early Morning Functional Impairments in Stimulant-Treated Children with Attention-Deficit/Hyperactivity Disorder Versus Controls: Impact on the Family.

作者信息

Faraone Stephen V, Schachar Russell J, Barkley Russell A, Nullmeier Rick, Sallee F Randy

机构信息

1 Departments of Psychiatry and Neuroscience and Physiology, SUNY Upstate Medical University , Syracuse, New York.

2 Department of Psychiatry and Research Institute, The Hospital for Sick Children, University of Toronto , Toronto, Canada .

出版信息

J Child Adolesc Psychopharmacol. 2017 Oct;27(8):715-722. doi: 10.1089/cap.2016.0164. Epub 2017 Apr 10.

DOI:10.1089/cap.2016.0164
PMID:28394175
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5651955/
Abstract

OBJECTIVE

Children with attention-deficit/hyperactivity disorder (ADHD) frequently manifest early morning functional (EMF) impairments before school. We conducted a quantitative research survey to assess the impact of these EMF impairments on the family unit (caregiver, spouse/partner, and siblings).

STUDY DESIGN

We developed an online survey questionnaire to collect data from 300 primary caregivers of children with ADHD and 50 primary caregivers of children who did not have ADHD.

RESULTS

Although the ADHD children we surveyed were currently treated with stable doses of stimulants as their primary ADHD medication for at least 3 months, their parents reported high levels of EMF impairments in the child, which had a substantial negative effect on the emotional well-being of parents, on parents' functioning during the early morning routine, and on the level of conflict with siblings. The impact of EMF impairments on family functioning was mediated by the severity of the index child's impairments.

CONCLUSIONS

EMF impairments exert a pervasive and significantly negative emotional and functional burden on not only the primary caregiver but also on the spouse/partner and siblings. This work suggests that adequate ADHD symptom control during the early morning period may be an unmet need for school-age children with ADHD being treated with stimulants. More work is needed to confirm this finding and determine the degree to which symptom control at other times of day is also an unmet need.

摘要

目的

注意缺陷多动障碍(ADHD)患儿在上学前经常出现清晨功能(EMF)损害。我们进行了一项定量研究调查,以评估这些EMF损害对家庭单位(照顾者、配偶/伴侣和兄弟姐妹)的影响。

研究设计

我们开发了一份在线调查问卷,以收集300名ADHD患儿的主要照顾者和50名非ADHD患儿的主要照顾者的数据。

结果

尽管我们调查的ADHD患儿目前至少3个月一直以稳定剂量的兴奋剂作为主要的ADHD药物进行治疗,但其父母报告称患儿存在高水平的EMF损害,这对父母的情绪健康、清晨日常活动中的功能以及与兄弟姐妹的冲突程度产生了重大负面影响。EMF损害对家庭功能的影响由索引儿童损害的严重程度介导。

结论

EMF损害不仅对主要照顾者,而且对配偶/伴侣和兄弟姐妹都施加了普遍且显著的负面情绪和功能负担。这项研究表明,对于接受兴奋剂治疗的学龄ADHD患儿,清晨期间充分控制ADHD症状可能是一项未得到满足的需求。需要更多的研究来证实这一发现,并确定一天中其他时间的症状控制未得到满足需求的程度。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/425b/5651955/65512f502599/fig-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/425b/5651955/963961e72f75/fig-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/425b/5651955/834e5b2d0889/fig-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/425b/5651955/65512f502599/fig-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/425b/5651955/963961e72f75/fig-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/425b/5651955/834e5b2d0889/fig-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/425b/5651955/65512f502599/fig-3.jpg

相似文献

1
Early Morning Functional Impairments in Stimulant-Treated Children with Attention-Deficit/Hyperactivity Disorder Versus Controls: Impact on the Family.与对照组相比,接受兴奋剂治疗的注意力缺陷/多动障碍儿童的清晨功能损害:对家庭的影响。
J Child Adolesc Psychopharmacol. 2017 Oct;27(8):715-722. doi: 10.1089/cap.2016.0164. Epub 2017 Apr 10.
2
Early Morning Functioning in Stimulant-Treated Children and Adolescents with Attention-Deficit/Hyperactivity Disorder, and its Impact on Caregivers.使用兴奋剂治疗的注意缺陷/多动障碍儿童和青少年的清晨功能及其对照顾者的影响。
J Child Adolesc Psychopharmacol. 2015 Sep;25(7):558-65. doi: 10.1089/cap.2014.0160. Epub 2015 Jul 7.
3
Association between quality of life and treatment response in children with attention Deficit Hyperactivity Disorder and their parents.注意缺陷多动障碍儿童及其父母的生活质量与治疗反应之间的关联
J Ment Health Policy Econ. 2014 Sep;17(3):119-29.
4
Caregiver Treatment Preferences for Children with a New Versus Existing Attention-Deficit/Hyperactivity Disorder Diagnosis.新诊断与已诊断注意缺陷多动障碍儿童的照料者治疗偏好
J Child Adolesc Psychopharmacol. 2017 Apr;27(3):234-242. doi: 10.1089/cap.2016.0157. Epub 2016 Dec 19.
5
Health-related quality of life in children and adolescents who have a diagnosis of attention-deficit/hyperactivity disorder.患有注意力缺陷/多动障碍的儿童和青少年的健康相关生活质量。
Pediatrics. 2004 Nov;114(5):e541-7. doi: 10.1542/peds.2004-0844.
6
Parent-Reported Improvements in Family Functioning in a Randomized Controlled Trial of Lisdexamfetamine for Treatment of Parental Attention-Deficit/Hyperactivity Disorder.在一项关于赖氨酸右旋苯丙胺治疗父母注意力缺陷/多动障碍的随机对照试验中,父母报告的家庭功能改善情况
J Child Adolesc Psychopharmacol. 2017 Apr;27(3):250-257. doi: 10.1089/cap.2016.0129. Epub 2016 Dec 19.
7
Sleep problems in children with attention-deficit/hyperactivity disorder: prevalence and the effect on the child and family.注意力缺陷/多动障碍儿童的睡眠问题:患病率及其对儿童和家庭的影响。
Arch Pediatr Adolesc Med. 2008 Apr;162(4):336-42. doi: 10.1001/archpedi.162.4.336.
8
A process for developing community consensus regarding the diagnosis and management of attention-deficit/hyperactivity disorder.一个就注意力缺陷/多动障碍的诊断和管理达成社区共识的过程。
Pediatrics. 2005 Jan;115(1):e97-104. doi: 10.1542/peds.2004-0953.
9
[Attention-deficit/hyperactivity disorder in childhood/adolescence and impairments associated with daily life: French data from the European Lifetime Impairment Survey].[儿童/青少年注意力缺陷/多动障碍及与日常生活相关的损害:来自欧洲终身损害调查的法国数据]
Arch Pediatr. 2014 Dec;21(12):1283-92. doi: 10.1016/j.arcped.2014.08.035. Epub 2014 Oct 7.
10
Parental angst making and revisiting decisions about treatment of attention-deficit/hyperactivity disorder.父母对于注意力缺陷/多动障碍治疗决策的焦虑及反复思考。
Pediatrics. 2009 Aug;124(2):580-9. doi: 10.1542/peds.2008-2569. Epub 2009 Jul 27.

引用本文的文献

1
A Phase 3, Placebo-Controlled Trial of Once-Daily Viloxazine Extended-Release Capsules in Adolescents With Attention-Deficit/Hyperactivity Disorder.一项关于每日一次维拉佐酮缓释胶囊治疗注意缺陷多动障碍青少年的 3 期安慰剂对照试验。
J Clin Psychopharmacol. 2021;41(4):370-380. doi: 10.1097/JCP.0000000000001404.
2
A Phase 3 Placebo-Controlled Trial of Once-Daily 400-mg and 600-mg SPN-812 (Viloxazine Extended-Release) in Adolescents with ADHD.一项为期 3 期、安慰剂对照、每日一次的 400mg 和 600mg SPN-812(Viloxazine 缓释片)治疗 ADHD 青少年的临床试验。
Psychopharmacol Bull. 2021 Mar 16;51(2):43-64.
3
Clinically Meaningful Improvements in Early Morning and Late Afternoon/Evening Functional Impairment in Children with ADHD Treated with Delayed-Release and Extended-Release Methylphenidate.

本文引用的文献

1
Attention-deficit/hyperactivity disorder.注意缺陷多动障碍。
Nat Rev Dis Primers. 2015 Aug 6;1:15020. doi: 10.1038/nrdp.2015.20.
2
Effect of drugs on the risk of injuries in children with attention deficit hyperactivity disorder: a prospective cohort study.药物对注意力缺陷多动障碍儿童受伤风险的影响:一项前瞻性队列研究。
Lancet Psychiatry. 2015 Aug;2(8):702-709. doi: 10.1016/S2215-0366(15)00271-0. Epub 2015 Jul 22.
3
Early Morning Functioning in Stimulant-Treated Children and Adolescents with Attention-Deficit/Hyperactivity Disorder, and its Impact on Caregivers.
接受延迟释放和缓释哌甲酯治疗的 ADHD 儿童在清晨和傍晚/晚间的功能障碍方面有临床意义上的改善。
J Atten Disord. 2022 Mar;26(5):696-705. doi: 10.1177/10870547211020073. Epub 2021 Jun 4.
4
Effect of Delayed-Release and Extended-Release Methylphenidate on Caregiver Strain and Validation of Psychometric Properties of the Caregiver Strain Questionnaire: Results from a Phase 3 Trial in Children with Attention-Deficit/Hyperactivity Disorder.延迟释放和延长释放哌甲酯对照顾者负担的影响及照顾者负担问卷心理测量学特性的验证:来自儿童注意缺陷多动障碍 3 期试验的结果。
J Child Adolesc Psychopharmacol. 2021 Apr;31(3):179-186. doi: 10.1089/cap.2020.0159. Epub 2021 Apr 1.
5
Model-Based Approach for Establishing the Predicted Clinical Response of a Delayed-Release and Extended-Release Methylphenidate for the Treatment of Attention-Deficit/Hyperactivity Disorder.基于模型的方法用于建立延迟释放和延长释放哌甲酯治疗注意缺陷/多动障碍的预测临床反应。
J Clin Psychopharmacol. 2020 Jul/Aug;40(4):350-358. doi: 10.1097/JCP.0000000000001222.
6
A Randomized, Double-Blind, Placebo-Controlled Study of HLD200, a Delayed-Release and Extended-Release Methylphenidate, in Children with Attention-Deficit/Hyperactivity Disorder: An Evaluation of Safety and Efficacy Throughout the Day and Across Settings.一项随机、双盲、安慰剂对照研究评估 HLD200(一种控释和缓释哌甲酯)治疗注意缺陷多动障碍儿童的安全性和疗效:全天和跨环境的评估。
J Child Adolesc Psychopharmacol. 2020 Feb;30(1):2-14. doi: 10.1089/cap.2019.0070. Epub 2019 Aug 29.
7
Sleep and daytime sleepiness in adolescents with and without ADHD: differences across ratings, daily diary, and actigraphy.青少年 ADHD 患者与非 ADHD 患者的睡眠与日间嗜睡:不同的评估方法、日常日记和活动记录仪的结果。
J Child Psychol Psychiatry. 2019 Sep;60(9):1021-1031. doi: 10.1111/jcpp.13061. Epub 2019 Apr 29.
8
Pharmacokinetics of HLD200, a Delayed-Release and Extended-Release Methylphenidate: Evaluation of Dose Proportionality, Food Effect, Multiple-Dose Modeling, and Comparative Bioavailability with Immediate-Release Methylphenidate in Healthy Adults.HLD200的药代动力学,一种缓释和长效释放的哌甲酯:在健康成年人中评价剂量比例、食物影响、多剂量模型以及与速释哌甲酯的比较生物利用度。
J Child Adolesc Psychopharmacol. 2019 Apr;29(3):181-191. doi: 10.1089/cap.2018.0122. Epub 2019 Feb 27.
9
Early-Onset Efficacy and Safety Pilot Study of Amphetamine Extended-Release Oral Suspension in the Treatment of Children with Attention-Deficit/Hyperactivity Disorder.苯丙胺缓释口服混悬液治疗儿童注意缺陷多动障碍的早期疗效与安全性初步研究
J Child Adolesc Psychopharmacol. 2019 Feb;29(1):2-8. doi: 10.1089/cap.2018.0078. Epub 2018 Dec 21.
10
Efficacy and Safety of HLD200, Delayed-Release and Extended-Release Methylphenidate, in Children with Attention-Deficit/Hyperactivity Disorder.缓释和长效释放型哌甲酯(HLD200)治疗注意缺陷/多动障碍儿童的疗效与安全性
J Child Adolesc Psychopharmacol. 2017 Aug;27(6):474-482. doi: 10.1089/cap.2017.0084. Epub 2017 Jul 21.
使用兴奋剂治疗的注意缺陷/多动障碍儿童和青少年的清晨功能及其对照顾者的影响。
J Child Adolesc Psychopharmacol. 2015 Sep;25(7):558-65. doi: 10.1089/cap.2014.0160. Epub 2015 Jul 7.
4
Reliability and Validity of the Before-School Functioning Scale in Children With ADHD.注意缺陷多动障碍儿童课前功能量表的信度和效度。
J Atten Disord. 2018 Sep;22(11):1040-1048. doi: 10.1177/1087054714564623. Epub 2015 Jan 9.
5
Trends in the parent-report of health care provider-diagnosed and medicated attention-deficit/hyperactivity disorder: United States, 2003-2011.医疗服务提供者诊断并用药治疗的注意力缺陷/多动障碍的家长报告趋势:美国,2003 - 2011年
J Am Acad Child Adolesc Psychiatry. 2014 Jan;53(1):34-46.e2. doi: 10.1016/j.jaac.2013.09.001. Epub 2013 Nov 21.
6
Morning and Evening Effects of Guanfacine Extended Release Adjunctive to Psychostimulants in Pediatric ADHD.胍法辛缓释剂辅助精神兴奋剂治疗小儿多动症的早晚效应
J Atten Disord. 2017 Jan;21(2):110-119. doi: 10.1177/1087054713500144. Epub 2016 Jul 28.
7
A controlled trial of the methylphenidate transdermal system on before-school functioning in children with attention-deficit/hyperactivity disorder.一项关于哌醋甲酯透皮贴剂对注意缺陷多动障碍儿童上学前功能影响的对照试验。
J Clin Psychiatry. 2010 May;71(5):548-56. doi: 10.4088/JCP.09m05779pur.
8
Atomoxetine versus stimulants in the community treatment of children with ADHD: an electronic diary study.阿托西汀与兴奋剂在 ADHD 儿童社区治疗中的比较:一项电子日记研究。
J Atten Disord. 2010 Jan;13(4):391-400. doi: 10.1177/1087054708325118.
9
Effects of atomoxetine and methylphenidate on sleep in children with ADHD.托莫西汀和哌甲酯对注意缺陷多动障碍儿童睡眠的影响。
Sleep. 2006 Dec;29(12):1573-85. doi: 10.1093/sleep/29.12.1573.
10
Toward mapping daily challenges of living with ADHD: maternal and child perspectives using electronic diaries.探索多动症患者日常生活挑战的映射:基于母婴视角的电子日记研究
J Abnorm Child Psychol. 2006 Feb;34(1):115-30. doi: 10.1007/s10802-005-9008-5. Epub 2006 Feb 4.