Jiménez-Domínguez Guadalupe, Ble-Castillo Jorge L, Aparicio-Trápala María A, Juárez-Rojop Isela E, Tovilla-Zárate Carlos A, Ble-Castillo Deysi J, García-Vázquez Carlos, Olvera-Hernández Viridiana, Pérez-Pimienta Bedelia, Diaz-Zagoya Juan C, Mendez José D
Endocrinology Department, General Hospital No. 46, Mexican Institute for Social Security, Villahermosa 86060, Mexico.
Metabolic Diseases Lab, Research Center, Academic Division of Health Sciences, Juarez Autonomous University of Tabasco, Villahermosa 86150, Mexico.
Int J Environ Res Public Health. 2015 Jul 6;12(7):7491-505. doi: 10.3390/ijerph120707491.
An abnormal glycemic profile, including postprandial glycemia and acute glucose spikes, precedes the onset of overt diabetes in obese subjects. Previous studies have shown the beneficial effects of chronic native banana starch (NBS) supplementation. In this study, we examined the effects of acute ingestion of NBS on glycemic profiles by means of continuous glucose monitoring in obese and lean subjects. In a crossover study, obese and lean subjects consumed beverages containing either 38.3 g of NBS or 38.3 g of digestible corn starch (DCS) twice daily during 4 days. On day 5, a 3-h meal tolerance test (MTT) was performed to evaluate glucose and insulin responses. After 1 week of washout period, treatments were inverted. NBS supplementation reduced the 48-h glycemia AUC in lean, obese, and in the combined group of lean and obese subjects in comparison with DCS. Postprandial glucose and insulin responses at MTT were reduced after NBS in comparison with DCS in all groups. However, no changes were observed in glycemic variability (GV) indexes between groups. In conclusion, acute NBS supplementation improved postprandial glucose and insulin responses in obese and lean subjects during 48 h of everyday life and at MTT. Further research to elucidate the mechanism behind these changes is required.
在肥胖受试者中，异常的血糖状况，包括餐后血糖和急性血糖峰值，先于显性糖尿病的发作。先前的研究表明，长期补充天然香蕉淀粉（NBS）具有有益效果。在本研究中，我们通过对肥胖和消瘦受试者进行连续血糖监测，研究了急性摄入NBS对血糖状况的影响。在一项交叉研究中，肥胖和消瘦受试者在4天内每天两次饮用含有38.3克NBS或38.3克可消化玉米淀粉（DCS）的饮料。在第5天，进行了一项3小时的餐耐量试验（MTT）以评估葡萄糖和胰岛素反应。经过1周的洗脱期后，处理方式颠倒。与DCS相比，补充NBS降低了消瘦、肥胖以及消瘦和肥胖受试者合并组的48小时血糖曲线下面积（AUC）。与DCS相比，所有组在MTT时餐后葡萄糖和胰岛素反应在补充NBS后均降低。然而，两组之间的血糖变异性（GV）指标没有变化。总之，急性补充NBS在日常生活的48小时内以及在MTT时改善了肥胖和消瘦受试者的餐后葡萄糖和胰岛素反应。需要进一步研究以阐明这些变化背后的机制。
