一种与致命性人类脑炎相关的斑驳松鼠博纳病毒。
A Variegated Squirrel Bornavirus Associated with Fatal Human Encephalitis.
机构信息
From the Institute of Diagnostic Virology (B.H., D.H., M.J., B.A., M.B.), Department of Experimental Animal Facilities and Biorisk Management (J.P.T.), and Institute of Novel and Emerging Infectious Diseases (R.G.U.), Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Bernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research, Hamburg (D.T., D.C., J.S.-C.), German Center for Infection Research (DZIF), Hamburg-Lübeck-Borstel (D.T., D.C., J.S.-C.), Institute of Veterinary Pathology, Justus-Liebig-University Gießen, Gießen (C.H.), Department of Neurology, Bergmannstrost Hospital (A.B., O.N.), and Department of Neurology, University Hospital Halle (Saale) (T.M.), Halle (Saale), Institute of Neuropathology, Otto-von-Guericke Universität, Magdeburg (C.M.), State Institute for Consumer Protection of Saxony-Anhalt, Department of Veterinary Medicine, Stendal (E.v.d.G.), and Special Service for Veterinarian Affairs and Consumer Protection, Salzlandkreis, Bernburg (Saale) (C.L.) - all in Germany.
出版信息
N Engl J Med. 2015 Jul 9;373(2):154-62. doi: 10.1056/NEJMoa1415627.
Between 2011 and 2013, three breeders of variegated squirrels (Sciurus variegatoides) had encephalitis with similar clinical signs and died 2 to 4 months after onset of the clinical symptoms. With the use of a metagenomic approach that incorporated next-generation sequencing and real-time reverse-transcriptase quantitative polymerase chain reaction (RT-qPCR), the presence of a previously unknown bornavirus was detected in a contact squirrel and in brain samples from the three patients. Phylogenetic analyses showed that this virus, tentatively named variegated squirrel 1 bornavirus (VSBV-1), forms a lineage separate from that of the known bornavirus species. (Funded by the Federal Ministry of Food and Agriculture [Germany] and others.).
2011 年至 2013 年间，3 位杂色松鼠（Sciurus variegatoides）饲养员出现脑炎，具有相似的临床症状，并在出现临床症状后 2 至 4 个月死亡。通过采用宏基因组方法，结合下一代测序和实时逆转录定量聚合酶链反应（RT-qPCR），在一只接触松鼠和 3 名患者的脑组织样本中检测到一种以前未知的博纳病毒。系统发育分析表明，这种病毒暂命名为杂色松鼠 1 博纳病毒（VSBV-1），与已知的博纳病毒种形成单独的谱系。（由德国联邦食品与农业部等资助）。
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