Feng Yun, Kuang Guopeng, Pan Yuanfei, Wang Jing, Yang Weihong, Wu Wei-Chen, Pan Hong, Wang Juan, Han Xi, Yang Lifen, Xin Gen-Yang, Shan Yong-Tao, Gou Qin-Yu, Liu Xue, Guo Deyin, Liang Guodong, Holmes Edward C, Gao Zihou, Shi Mang
State Key Laboratory of Remote Sensing Science, Center for Global Change and Public Health, Faculty of Geographical Science, Beijing Normal University, Beijing 100875, China.
Yunnan Provincial Key Laboratory for Zoonosis Control and Prevention, Yunnan Institute of Endemic Disease Control and Prevention, Dali 671000, China.
Natl Sci Rev. 2024 Dec 17;12(6):nwae463. doi: 10.1093/nsr/nwae463. eCollection 2025 Jun.
Metagenomic sequencing has transformed the understanding of viral diversity in wildlife and the potential threats these viruses pose to human health. Despite this progress, such sequencing studies often have lacked systematic and ecologically informed sampling, thereby likely missing many potential human pathogens and the drivers behind their ecology, evolution and emergence. We conducted an extensive search for viruses in the lungs, spleens and guts of 1688 mammals from 38 species across 428 sites in Yunnan Province, China-a hotspot for zoonoses emergence. We identified 162 mammalian viruses, including 102 new ones and 24 posing potential risks to humans due to their relationships with known human pathogens associated with serious diseases or their ability to cross major host species barriers. Our findings offer an in-depth view of virus organotropism, cross-host associations, host sharing patterns, and the ecological factors influencing viral evolution, all of which are critical for anticipating and mitigating future zoonotic outbreaks.
宏基因组测序改变了我们对野生动物中病毒多样性以及这些病毒对人类健康构成的潜在威胁的认识。尽管取得了这一进展，但此类测序研究往往缺乏系统且基于生态学的采样，因此很可能遗漏了许多潜在的人类病原体及其生态、进化和出现背后的驱动因素。我们在中国云南省428个地点对来自38个物种的1688只哺乳动物的肺、脾脏和肠道进行了广泛的病毒搜索，云南省是动物源性疾病出现的热点地区。我们鉴定出162种哺乳动物病毒，其中包括102种新病毒，以及24种因其与已知的与严重疾病相关的人类病原体的关系或其跨越主要宿主物种屏障的能力而对人类构成潜在风险的病毒。我们的研究结果提供了对病毒嗜器官性、跨宿主关联、宿主共享模式以及影响病毒进化的生态因素的深入了解，所有这些对于预测和缓解未来的人畜共患病疫情都至关重要。
