Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Bio-functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Jiangsu 210023, China.
Jiangsu Engineering Research Center of Interfacial Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Jiangsu 210093, China.
J Mater Chem B. 2022 May 18;10(19):3687-3695. doi: 10.1039/d2tb00429a.
Bacterial-associated infection, blood coagulation, and tissue adhesion are severe issues associated with biomedical implants and devices in clinic applications. Here, we report a general strategy to simultaneously tackle these issues on polyurethane (PU)-based substrates. Taking advantage of reversible addition-fragmentation chain transfer (RAFT) polymerization, well-defined zwitterionic/active ester block polymers (pSBMA--pNHSMA) with an identical pNHSMA segment (polymerization degree of 15) but varied zwitterionic pSBMA segments (polymerization degrees of 40 and 100) were precisely prepared. The pSBMA--pNHSMA block polymers could be easily covalently constructed on PU substrates that were pretreated with a polydopamine coating based on highly efficient anime-active ester chemistry, as evidenced by the water contact angle and XPS tests. The relationship between the length of pSBMA segments in the coating and the antifouling ability of PU substrates was established. The results indicated that block polymers with a pSBMA segment of 40 repeat units could significantly prevent protein adsorption, bacterial/platelet adhesion, and cell attachment on PU substrates within 24 h, while a longer pSBMA segment (repeat units of 100) could endow long-term antibacterial (14 days without biofilm formation) and anti-cell attachment (5 days without cell attachment) properties to the PU substrates. Furthermore, the coating significantly improved the surface lubricating property of PU substrates without compromising on the mechanical property. This strategy may find many applications in PU-based implants and devices.
细菌相关感染、血液凝固和组织黏附是临床应用中生物医学植入物和设备中存在的严重问题。在这里，我们报告了一种在基于聚氨基甲酸酯（PU）的基底上同时解决这些问题的通用策略。利用可逆加成-断裂链转移（RAFT）聚合，精确制备了具有相同 pNHSMA 段（聚合度为 15）但不同两性离子 pSBMA 段（聚合度为 40 和 100）的两性离子/活性酯嵌段聚合物（pSBMA--pNHSMA）。pSBMA--pNHSMA 嵌段聚合物可以很容易地通过基于高效偶氮-活性酯化学的聚多巴胺涂层预处理共价构建在 PU 基底上，这可以通过水接触角和 XPS 测试得到证明。建立了涂层中 pSBMA 段长度与 PU 基底抗污能力之间的关系。结果表明，具有 40 个重复单元的 pSBMA 段的嵌段聚合物可以显著防止蛋白质吸附、细菌/血小板黏附和细胞黏附在 24 h 内的 PU 基底上，而较长的 pSBMA 段（重复单元为 100）可以赋予 PU 基底长期的抗菌（14 天不形成生物膜）和抗细胞黏附（5 天不黏附细胞）性能。此外，该涂层在不影响机械性能的情况下显著改善了 PU 基底的表面润滑性能。这种策略可能在基于 PU 的植入物和设备中有许多应用。
