甲基东莨菪碱与条件性位置回避

Methylscopolamine and conditioned location avoidance.

作者信息

Hughes R N, Blampied N M, Anderson G J, Woollett G J

机构信息

Department of Psychology, University of Canterbury, Christchurch, New Zealand.

出版信息

Pharmacol Biochem Behav. 1989 Aug;33(4):913-4. doi: 10.1016/0091-3057(89)90492-9.

DOI:10.1016/0091-3057(89)90492-9

PMID:2616611

Abstract

On alternate days, rats were confined to one side of a shuttlebox following IP administration of saline and to the other following the peripherally-acting muscarinic antagonist, methylscopolamine (1.2 mg/kg). They later avoided the side associated with the drug effect. By duplicating an earlier finding with centrally- and peripherally-acting scopolamine, this result identified aversive peripheral actions of the two drugs as mainly responsible for the effects observed.

摘要

每隔一天，在腹腔注射生理盐水后，将大鼠限制在穿梭箱的一侧，在注射外周作用的毒蕈碱拮抗剂甲基东莨菪碱（1.2毫克/千克）后，将大鼠限制在穿梭箱的另一侧。随后，大鼠避开了与药物作用相关的那一侧。通过重复之前使用中枢和外周作用的东莨菪碱的研究结果，该结果表明这两种药物的外周厌恶作用是观察到的效应的主要原因。