Bonaccorsi Gloria, Romani Arianna, Cremonini Eleonora, Bergamini Carlo M, Castaldini Maria Cristina, Fila Enrica, Hanau Stefania, Massari Leo, Cervellati Carlo
Department of Morphology, Surgery and Experimental Medicine, Menopause and Osteoporosis Centre, University of Ferrara, Ferrara, Italy; Department of Morphology, Surgery and Experimental Medicine, Section of Gynaecology and Obstetrics, University of Ferrara, Ferrara, Italy.
Department of Biomedical and Specialist Surgical Sciences, Section of Medical Biochemistry, Molecular Biology and Genetics, University of Ferrara, Ferrara, Italy.
Taiwan J Obstet Gynecol. 2015 Jun;54(3):290-3. doi: 10.1016/j.tjog.2014.09.009.
At present, there is growing demand for alternative, or additional, treatments to hormone replacement therapy for menopause-related hot flashes (HF). Antioxidant supplements have been recently proposed as possible candidates for this purpose, regardless of the absence of clear evidence in support of a link between these vasomotor symptoms and oxidative stress (OxS). The aim of our study was to evaluate the association between HF and OxS serum markers in a large sample of middle-aged women.
We conducted a cross-sectional study on 245 perimenopausal and early postmenopausal women (age 45-60 years). The variables examined were presence of self-reported HF and levels of 8-iso-prostaglandin F2α, 8-OH-deoxy-2'-guanosine, advanced oxidation protein products, total antioxidant power, uric acid, thiols, and paroxonase-1.
Seventy-six women (31%) reported to suffer from HF (either medium or high intensity). None of the peripheral markers of OxS examined was found to be significantly associated with the presence of HF.
Taken together, our data suggest that systemic OxS might not be implicated with the onset of the climacteric vasomotor symptoms that most commonly affect women experiencing perimenopause and early postmenopause.
目前，对于更年期相关潮热（HF）而言，激素替代疗法的替代或辅助治疗需求日益增长。尽管缺乏明确证据支持这些血管舒缩症状与氧化应激（OxS）之间存在关联，但抗氧化剂补充剂最近已被提议作为实现此目的的可能选择。我们研究的目的是在大量中年女性样本中评估HF与OxS血清标志物之间的关联。
我们对245名围绝经期和绝经后早期女性（年龄45 - 60岁）进行了一项横断面研究。所检查的变量包括自我报告的HF情况以及8 - 异前列腺素F2α、8 - 羟基脱氧鸟苷、晚期氧化蛋白产物、总抗氧化能力、尿酸、硫醇和对氧磷酶 - 1的水平。
76名女性（31%）报告患有HF（中度或高强度）。在所检查的OxS外周标志物中，未发现任何一项与HF的存在有显著关联。
综合来看，我们的数据表明全身OxS可能与更年期血管舒缩症状的发作无关，这些症状最常影响围绝经期和绝经后早期的女性。
