Lu Qi, Ye Fang, Yang Xiangjun, Gu Qingqing, Wang Peng, Zhu Jianhua, Shen Li, Gong Feirong
Department of Cardiology, Affiliated Hospital of Nantong University, Nantong 226001, China.
Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.
Biomed Res Int. 2015;2015:291871. doi: 10.1155/2015/291871. Epub 2015 Jun 8.
Curcumin was reported to exhibit a wide range of pharmacological effects including antioxidant, anti-inflammatory, and antiproliferative activities and significantly prevent smooth muscle cells migration. In the present study, a novel kind of curcumin loaded nanoparticles (Cur-NP) has been prepared and characterized with the aim of inhibiting inflammation formation and accelerating the healing process of the stented arteries. Cur-NP was administrated intravenously after stent implantation twice a week and detailed tissue responses were evaluated. The results demonstrated that intravenous administration of Cur-NP after stent implantation accelerated endothelial cells restoration and endothelium function recovery and may potentially be an effective therapeutic alternative to reduce adverse events for currently available drug eluting stents.
据报道，姜黄素具有广泛的药理作用，包括抗氧化、抗炎和抗增殖活性，并能显著抑制平滑肌细胞迁移。在本研究中，制备并表征了一种新型的负载姜黄素的纳米颗粒（Cur-NP），旨在抑制炎症形成并加速支架置入动脉的愈合过程。在支架植入后每周两次静脉注射Cur-NP，并评估详细的组织反应。结果表明，支架植入后静脉注射Cur-NP可加速内皮细胞修复和内皮功能恢复，可能是减少现有药物洗脱支架不良事件的一种有效治疗选择。
