Ho T T B, Groer M W, Luciano A A, Schwartz A, Ji M, Miladinovic B S, Maheshwari A, Ashmeade T L
Department of Pediatrics, University of South Florida, Tampa, FL, USA.
College of Nursing, University of South Florida, Tampa, FL, USA.
J Perinatol. 2015 Oct;35(10):837-41. doi: 10.1038/jp.2015.73. Epub 2015 Jul 16.
We hypothesized that red blood cell (RBC) transfusions influence intestinal inflammation in very low birth weight (VLBW) infants. We also suspected that hematocrit (Hct) at transfusions and RBC storage time correlate with intestinal inflammation.
VLBW infants, without major congenital defects, intestinal perforation or necrotizing enterocolitis, were enrolled prospectively. Fecal calprotectin (FC) levels were measured from stool samples collected before and after RBC transfusions. Data on Hct and RBC storage time were collected.
Data from 42 RBC transfusions given to 26 infants revealed that FC levels increased faster than baseline after RBC transfusions (P=0.018) and were higher in multiple-transfused infants (0 to 48 and >48 h post transfusion, P=0.007 and P=0.005, respectively). Lower Hct and RBC storage >21 days correlated with higher FC levels (P=0.044 and P=0.013, respectively).
RBC transfusions, anemia and prolonged RBC storage were associated with an increase in intestinal inflammation.
我们推测红细胞（RBC）输血会影响极低出生体重（VLBW）婴儿的肠道炎症。我们还怀疑输血时的血细胞比容（Hct）和红细胞储存时间与肠道炎症相关。
前瞻性纳入无重大先天性缺陷、肠道穿孔或坏死性小肠结肠炎的极低出生体重婴儿。在红细胞输血前后收集的粪便样本中测量粪便钙卫蛋白（FC）水平。收集有关血细胞比容和红细胞储存时间的数据。
对26名婴儿进行的42次红细胞输血数据显示，红细胞输血后粪便钙卫蛋白水平升高速度快于基线（P = 0.018），多次输血婴儿在输血后0至48小时和>48小时时粪便钙卫蛋白水平更高（分别为P = 0.007和P = 0.005）。较低的血细胞比容和红细胞储存>21天与较高的粪便钙卫蛋白水平相关（分别为P = 0.044和P = 0.013）。
红细胞输血、贫血和红细胞长时间储存与肠道炎症增加有关。
