代谢组学在脑代谢研究中的作用。
The Role of Metabolomics in Brain Metabolism Research.
作者信息
Ivanisevic Julijana, Siuzdak Gary
机构信息
Scripps Center for Metabolomics and Mass Spectrometry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA.
出版信息
J Neuroimmune Pharmacol. 2015 Sep;10(3):391-5. doi: 10.1007/s11481-015-9621-1. Epub 2015 Jul 23.
Abstract
This special edition of the Journal of Neuroimmune Pharmacology focuses on the leading edge of metabolomics in brain metabolism research. The topics covered include a metabolomic field overview and the challenges in neuroscience metabolomics. The workflow and utility of different analytical platforms to profile complex biological matrices that include biofluids, brain tissue and cells, are shown in several case studies. These studies demonstrate how global and targeted metabolite profiling can be applied to distinguish disease stages and to understand the effects of drug action on the central nervous system (CNS). Finally, we discuss the importance of metabolomics to advance the understanding of brain function that includes ligand-receptor interactions and new insights into the mechanisms of CNS disorders.
摘要
《神经免疫药理学杂志》的这一特刊聚焦于脑代谢研究中代谢组学的前沿领域。涵盖的主题包括代谢组学领域概述以及神经科学代谢组学中的挑战。在多个案例研究中展示了不同分析平台用于分析包括生物流体、脑组织和细胞在内的复杂生物基质的工作流程和效用。这些研究表明如何应用全局和靶向代谢物谱分析来区分疾病阶段，并了解药物作用于中枢神经系统（CNS）的效果。最后，我们讨论了代谢组学对于推进对脑功能的理解的重要性，这包括配体 - 受体相互作用以及对中枢神经系统疾病机制的新见解。
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