Ricciardi Carlo Alberto, Lacquaniti Antonio, Cernaro Valeria, Bruzzese Annamaria, Visconti Luca, Loddo Saverio, Santoro Domenico, Buemi Michele
Department of Clinical and Experimental Medicine, University Hospital of Messina, 98100, Messina, Italy.
Department of Pathology, University of Messina, Messina, Italy.
Clin Exp Med. 2016 Aug;16(3):443-9. doi: 10.1007/s10238-015-0374-1. Epub 2015 Jul 24.
Natriuretic peptides (NP) play a key role in regulation of salt and water balance. Corin, a serine protease which activates NP, plays a key role in regulation of blood pressure and cardiac function. The aim of the study was to evaluate the involvement of corin in renal physiopathology, analyze its levels in dialyzed patients and evaluate its relation with fluid overload and comorbidities such as heart failure and blood hypertension. We studied serum corin in uremic patients (n = 20) undergoing hemodialysis therapy (HD) and in healthy subjects (HS). Corin levels in uremic patients were higher than in HS (p < 0.0001). Moreover, its concentration did not change after a single HD session. Hypertensive patients and subject suffering from heart failure were characterized by high values of corin. After multivariate analysis, direct correlations were maintained between corin and dialysis vintage (β = 0.83; p = 0.0002), heart failure (β = 0.42; p < 0.0001), systolic blood pressure (β = -0.70; p = 0.0002) and body weight (β = -0.39; p < 0.0001). Corin might be implicated in the regulation of salt and water balance and the disturbances of volume homeostasis of HD patients. However, further studies are warranted to understand the role of corin in kidney diseases and to define its diagnostic and prognostic role.
利钠肽（NP）在盐和水平衡调节中起关键作用。Corin是一种激活NP的丝氨酸蛋白酶，在血压和心脏功能调节中起关键作用。本研究的目的是评估Corin在肾脏生理病理学中的作用，分析其在透析患者中的水平，并评估其与液体超负荷以及心力衰竭和高血压等合并症的关系。我们研究了接受血液透析治疗（HD）的尿毒症患者（n = 20）和健康受试者（HS）的血清Corin。尿毒症患者的Corin水平高于HS（p < 0.0001）。此外，单次HD治疗后其浓度没有变化。高血压患者和心力衰竭患者的Corin值较高。多变量分析后，Corin与透析龄（β = 0.83；p = 0.0002）、心力衰竭（β = 0.42；p < 0.0001）、收缩压（β = -0.70；p = 0.0002）和体重（β = -0.39；p < 0.0001）之间保持直接相关性。Corin可能参与HD患者的盐和水平衡调节以及容量稳态紊乱。然而，需要进一步研究以了解Corin在肾脏疾病中的作用，并确定其诊断和预后作用。
