Vancampfort Davy, Guelinckx Hannes, Probst Michel, Stubbs Brendon, Rosenbaum Simon, Ward Philip B, De Hert Marc
Department of Rehabilitation Sciences, KU Leuven - University of Leuven, Leuven, Belgium.
Department of Neurosciences, KU Leuven - University of Leuven, Kortenberg, Belgium.
Int J Ment Health Nurs. 2015 Oct;24(5):394-402. doi: 10.1111/inm.12145. Epub 2015 Jul 28.
The purpose of this cross-sectional study was to investigate whether aerobic fitness contributes to the health-related quality of life (HRQoL) in people with schizophrenia, while adjusting for other previously-established contributory factors. Thirty-four male (34.1 ± 12.0 years) and 13 female (34.3 ± 9.2 years) participants performed a submaximal Astrand-Rhyming cycle ergometer test and completed the 36-item Short-Form Health Survey, the International Physical Activity Questionnaire, and the Psychosis Evaluation tool for Common Use by Caregivers. After controlling for age and sex, illness duration (12.4 ± 11.2 years, r(2) = 0.38, P < 0.001), fewer positive (9.3 ± 4.3, r(2) = 0.30, P = 0.006) and cognitive (8.4 ± 3.8, r(2) = 0.28, P = 0.011) symptoms, and higher aerobic fitness (34.5 ± 8.7 ml O2 min(-1) kg(-1), r(2) = 0.36, P = 0.001) were found to be independent significant predictors of physical HRQoL (mean score 66.6 ± 18.5). However, when all variables were included in the same regression model, only illness duration (P = 0.004) and positive symptoms (P = 0.045) remained significant predictors, while there was a trend (P < 0.10) for age and aerobic fitness. The final model explained 54% of the variability in physical HRQoL. No significant correlates for mental HRQoL (54.9 ± 18.5) were found. People with schizophrenia might improve their physical HRQoL by improving their aerobic fitness. Mental health nurses should assist in facilitating improvements in aerobic fitness through facilitating physical activity participation in patients with schizophrenia.
这项横断面研究的目的是，在对其他先前确定的影响因素进行校正的同时，调查有氧适能是否有助于精神分裂症患者的健康相关生活质量（HRQoL）。34名男性（34.1±12.0岁）和13名女性（34.3±9.2岁）参与者进行了次极量阿斯兰德-莱明循环测力计测试，并完成了36项简短健康调查问卷、国际体力活动问卷以及照顾者常用的精神病评估工具。在控制年龄和性别后，发现病程（12.4±11.2年，r² = 0.38，P < 0.001）、较少的阳性症状（9.3±4.3，r² = 0.30，P = 0.006）和认知症状（8.4±3.8，r² = 0.28，P = 0.011）以及较高的有氧适能（34.5±8.7 ml O₂ min⁻¹ kg⁻¹，r² = 0.36，P = 0.001）是身体HRQoL（平均得分66.6±18.5）的独立显著预测因素。然而，当所有变量纳入同一回归模型时，只有病程（P = 0.004）和阳性症状（P = 0.045）仍然是显著预测因素，而年龄和有氧适能存在一种趋势（P < 0.10）。最终模型解释了身体HRQoL中54%的变异性。未发现与精神HRQoL（54.9±18.5）有显著相关性。精神分裂症患者可能通过改善有氧适能来提高其身体HRQoL。心理健康护士应协助通过促进精神分裂症患者参与体育活动来推动有氧适能的改善。
