小鼠桶状皮层中组织型纤溶酶原激活物的细胞类型特异性
Cell type specificity of tissue plasminogen activator in the mouse barrel cortex.
作者信息
Chu Philip, Chen Eric, Bajnath Adesh, Brumberg Joshua C
机构信息
Neuropsychology doctoral program, The Graduate Center, City University of New York (CUNY), United States.
Neuropsychology doctoral program, The Graduate Center, City University of New York (CUNY), United States ; University of California, Santa Cruz, United States.
出版信息
Data Brief. 2015 Jun 25;4:332-5. doi: 10.1016/j.dib.2015.06.008. eCollection 2015 Sep.
We provide data in this article related to (C.C. Chen et al.,. Neurosci. Lett., 599 (2015) 152-157.) [1] where the expression of tissue plasminogen activator (tPA) is expressed by the whisker representation in the somatosensory cortex. Here, we provide immunocytochemistry data indicating that tPA is expressed by putative excitatory neurons as well as parvalbumin+ interneurons but not by somatostatin+ inhibitory interneurons. We also provide data showing that microglia do not normally express high levels of tPA, but upregulate their levels following cortical penetration with a recording electrode.
我们在本文中提供了与（C.C. 陈等人，《神经科学快报》，599 (2015) 152 - 157.）[1]相关的数据，其中组织型纤溶酶原激活剂（tPA）的表达由体感皮层中的触须表征所呈现。在此，我们提供免疫细胞化学数据表明，tPA 由假定的兴奋性神经元以及小白蛋白阳性中间神经元表达，但不由生长抑素阳性抑制性中间神经元表达。我们还提供数据显示，小胶质细胞通常不表达高水平的 tPA，但在用记录电极穿透皮层后其水平会上调。
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