Struijs Peter A A, Kerkhoffs Gino M M J
Academic Medical Center, Amsterdam, The Netherlands.
BMJ Clin Evid. 2015 Jul 28;2015:1115.
Injury of the lateral ligament complex of the ankle joint occurs in about one in 10,000 people per day, accounting for a quarter of all sports injuries.
We conducted a systematic overview, aiming to answer the following clinical question: What are the effects of non-steroidal anti-inflammatory drugs (NSAIDs) in the treatment of acute ankle sprains? We searched: Medline, Embase, The Cochrane Library, and other important databases up to April 2014 (Clinical Evidence overviews are updated periodically; please check our website for the most up-to-date version of this overview).
At this update, searching of electronic databases retrieved 158 studies. After deduplication and removal of conference abstracts, 97 records were screened for inclusion in the overview. Appraisal of titles and abstracts led to the exclusion of 48 studies and the further review of 49 full publications. Of the 49 full articles evaluated, one systematic review and four RCTs were added. We performed a GRADE evaluation for four PICO combinations.
In this systematic overview, we categorised the efficacy for three interventions, based on information relating to the effectiveness and safety of oral NSAIDs versus placebo, oral versus topical NSAIDs, selective COX-2 inhibitors versus other NSAIDs, and topical NSAIDs versus placebo.
踝关节外侧韧带复合体损伤的发生率约为每天万分之一，占所有运动损伤的四分之一。
我们进行了一项系统综述，旨在回答以下临床问题：非甾体抗炎药（NSAIDs）治疗急性踝关节扭伤的效果如何？我们检索了：截至2014年4月的Medline、Embase、Cochrane图书馆及其他重要数据库（临床证据综述会定期更新；请查看我们的网站获取此综述的最新版本）。
在本次更新中，检索电子数据库获得158项研究。在去除重复项和会议摘要后，筛选出97条记录以纳入综述。对标题和摘要的评估导致排除48项研究，并对49篇全文进行进一步审查。在评估的49篇全文中，增加了1篇系统综述和4项随机对照试验。我们对四种PICO组合进行了GRADE评估。
在本系统综述中，我们根据口服NSAIDs与安慰剂、口服与外用NSAIDs、选择性COX-2抑制剂与其他NSAIDs以及外用NSAIDs与安慰剂的有效性和安全性信息，对三种干预措施的疗效进行了分类。
