用于自噬体小管的剪刀。
Scissors for autolysosome tubules.
机构信息
The State Key Laboratory of Membrane Biology, Tsinghua University-Peking University Joint Center for Life Sciences School of Life Sciences Tsinghua University, Beijing, China.
出版信息
EMBO J. 2015 Sep 2;34(17):2217-8. doi: 10.15252/embj.201592519. Epub 2015 Jul 28.
Abstract
Autophagic lysosome reformation (ALR) is a cellular process in which lysosomes are reformed through scission of proto-lysosomes from tubular structures extruded from autolysosomes. Despite recent progress, the molecular mechanism of ALR is far from clear. A paper in this issue of has identified lysosome-localized PI(3)P, which is generated by the VPS34–UVRAG complex in an mTOR-dependent manner, as an important regulator of autolysosome tubule scission (Munson , 2015).
摘要
自噬溶酶体再形成（ALR）是一种细胞过程，其中溶酶体通过从自溶酶体中伸出的管状结构中分离前溶酶体而重新形成。尽管最近取得了进展，但 ALR 的分子机制还远未清楚。本期杂志中的一篇论文已经确定了溶酶体定位的 PI(3)P，它是由 VPS34–UVRAG 复合物在 mTOR 依赖性方式下产生的，是自噬溶酶体管段分裂的重要调节因子（Munson, 2015）。
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本文引用的文献
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Lipid droplet breakdown requires dynamin 2 for vesiculation of autolysosomal tubules in hepatocytes.脂滴分解需要 dynamin 2 来实现肝细胞自噬小体管的囊泡化。
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