多形核白细胞的功能与 Jorge Lobo 病的个体性：不存在针对巴西副球孢子菌的特异性白细胞消化缺陷。

Functions of polymorphonuclear leukocytes and individuality of Jorge Lobo's disease: absence of the specific leukocyte digestive defect against Paracoccidioides brasiliensis.

作者信息

Goihman-Yahr M, Cabello de Brito I, Bastardo de Albornoz M C, de Gomez M H, Pereira J, de Román A, San Martín B, Molina T

出版信息

Mycoses. 1989 Dec;32(12):603-8. doi: 10.1111/j.1439-0507.1989.tb02190.x.

DOI:10.1111/j.1439-0507.1989.tb02190.x

PMID:2622474

Abstract

Peripheral blood neutrophils (PMNs) from a patient with Jorge Lobo's disease (JLD) digested well phagocytosed Paracoccidioides brasiliensis. We found no circulating antibodies against P. brasiliensis in the patient's serum. Such neutrophils showed myeloperoxidase activity and also digested normally phagocytosed Candida albicans. We had previously reported the presence of a specific digestive deficiency of PMNs from patients with paracoccidioidomycosis (PARA) vis à vis P. brasiliensis. Current findings provide new information about leukocyte functions in JLD and bolster the view that JLD, PARA and their respective causative microorganisms are distinct.

摘要

来自一名患有 Jorge Lobo 病（JLD）患者的外周血中性粒细胞（PMN）能够很好地消化吞噬巴西副球孢子菌。我们在患者血清中未发现针对巴西副球孢子菌的循环抗体。这类中性粒细胞显示出髓过氧化物酶活性，并且也能正常消化吞噬白色念珠菌。我们之前曾报道过，相对于巴西副球孢子菌，副球孢子菌病（PARA）患者的 PMN 存在特定的消化缺陷。目前的研究结果提供了关于 JLD 中白细胞功能的新信息，并支持了 JLD、PARA 及其各自致病微生物是不同的这一观点。