Restrepo A, Vélez H
Sabouraudia. 1975 Mar;13 Pt 1:10-21.
Peripheral leukocytes from 17 patients with paracoccidioidomycosis were mixed with yeast cells from Paracoccidioides brasiliensis and Rhodotorula sp. to ascertain their phagocytic and lytic capacities. The role of circulating antibodies in the process was also investigated by the use of autologous serum. The phagocytic capacity of the leukocytes was found to be normal for both types of yeasts. However, in the presence of the patient's serum, the percentage of P. brasiliensis cells ingested was increased (P smaller than or equql to 0.02). Furthermore, in 70-5% of the cases the lytic process was increased and more P. brasiliensis cells were killed when such a serum was employed (P smaller than or equal to 0.0013). This increased effect was not recorded for Rhodotorula sp. cells, thus indicating specificity. The peripheral leukocytes from patients with paracoccidioidomycosis are not defective. However, the success of the phagocytic process is aided by the opsonic action of the specific antibodies in the patient's serum.
将17例副球孢子菌病患者的外周血白细胞与巴西副球孢子菌和红酵母属的酵母细胞混合，以确定其吞噬和溶解能力。还通过使用自体血清研究了循环抗体在该过程中的作用。发现白细胞对两种酵母的吞噬能力均正常。然而，在患者血清存在的情况下，巴西副球孢子菌细胞的摄取百分比增加（P小于或等于0.02）。此外，在70 - 5%的病例中，当使用这种血清时，溶解过程增强，更多的巴西副球孢子菌细胞被杀死（P小于或等于0.0013）。对于红酵母属细胞未记录到这种增强作用，从而表明具有特异性。副球孢子菌病患者的外周血白细胞没有缺陷。然而，患者血清中特异性抗体的调理作用有助于吞噬过程的成功。
