心肌甘油三酯含量的年龄依赖性：一项3T高场1H磁共振波谱研究。

Age Dependency of Myocardial Triglyceride Content: A 3T High-Field 1H-MR Spectroscopy Study.

作者信息

Petritsch B, Gassenmaier T, Kunz A S, Donhauser J, Goltz J P, Bley T A, Horn M

机构信息

Institute of Diagnostic and Interventional Radiology, University Hospital of Würzburg, Würzburg, Germany.

Clinic for Radiology and Nuclear Medicine, University Hospital of Schleswig-Holstein, Campus Lübeck, Germany.

出版信息

Rofo. 2015 Nov;187(11):1016-21. doi: 10.1055/s-0035-1553350. Epub 2015 Jul 31.

DOI:10.1055/s-0035-1553350

PMID:26230138

Abstract

PURPOSE

The role of myocardial triglyceride (mTG) content in the aging human heart is not entirely understood. The aim of this study was to measure concentrations of mTG content from healthy volunteers and to determine the association between age, mTG content and systolic heart function. Furthermore, the technical stability of the (1)H-magnetic resonance spectroscopy ((1)H-MRS) and the reliability of peak evaluation at 3 T were evaluated.

MATERIALS AND METHODS

The total study population of 47 healthy volunteers was divided into 4 age classes, according to the age of the subjects (1(st) cohort 20 - 29 years (yrs.), n = 20; 2(nd) cohort 30 - 39 yrs., n = 10; 3(rd) cohort 40 - 49 yrs., n = 9; 4(th) cohort 50 - 60 yrs., n = 8). Cardiac MRI and double triggered (1)H-MRS of the myocardium were consecutively performed using a 3 T scanner. Each participant underwent spectroscopic measurements twice in the same investigation.

RESULTS

mTG content increases with age. The correlation of age and mTG is minimal (r = 0.48; p < 0.001). The following age-averaged mTG content values expressed as % of mTG signal compared to the water signal were determined for each cohort: 1(st) cohort 0.25 % (± 0.17); 2(nd) cohort 0.48 % (± 0.30); 3(rd) cohort 0.48 % (± 0.18); 4(th) cohort 0.77 % (± 0.70). There was no significant correlation (r = 0.04; p = n.s.) between LV mass and mTG content in healthy volunteers. Within our cohorts, no effects of age or mTG content on systolic heart function were seen (r = - 0.01; p = n.s.). The intraclass correlation coefficient of spectroscopic measurements was high (r = 0.965; p < 0.001).

CONCLUSION

Myocardial TG content increases with age. The normal age-dependent concentration ranges of myocardial lipid metabolites reported in this study may be helpful for the correction of acquired (1)H-MRS data in patients when evaluating metabolic and cardiovascular diseases in future magnetic resonance spectroscopy studies.

摘要

目的

心肌甘油三酯（mTG）含量在衰老的人类心脏中的作用尚未完全明确。本研究旨在测量健康志愿者的mTG含量，并确定年龄、mTG含量与心脏收缩功能之间的关联。此外，还评估了3T场强下氢磁共振波谱（¹H-MRS）的技术稳定性以及波峰评估的可靠性。

材料与方法

根据受试者年龄，将47名健康志愿者的总研究人群分为4个年龄组（第1组20 - 29岁，n = 20；第2组30 - 39岁，n = 10；第3组40 - 49岁，n = 9；第4组50 - 60岁，n = 8）。使用3T扫描仪连续进行心脏MRI和心肌双触发¹H-MRS检查。在同一次检查中，每位参与者均接受两次波谱测量。

结果

mTG含量随年龄增长而增加。年龄与mTG的相关性较弱（r = 0.48；p < 0.001）。为每个年龄组确定了以下以mTG信号相对于水信号的百分比表示的年龄平均mTG含量值：第1组0.25%（±0.17）；第2组0.48%（±0.30）；第3组0.48%（±0.18）；第4组0.77%（±0.70）。在健康志愿者中，左心室质量与mTG含量之间无显著相关性（r = 0.04；p = 无统计学意义）。在我们的年龄组中，未观察到年龄或mTG含量对心脏收缩功能有影响（r = -0.01；p = 无统计学意义）。波谱测量的组内相关系数较高（r = 0.965；p < 0.001）。