Gupta Ashish, Houston Brian
Centre of Biomedical Research, SGPGIMS Campus, Lucknow, India.
Division of Cardiology, The Medical University of South Carolina, Charleston, SC, USA.
Heart Fail Rev. 2021 Jul;26(4):839-859. doi: 10.1007/s10741-020-10059-5. Epub 2021 Jan 7.
Continued advances in laboratory medicine are required to realize the potential of individualized medicine to impact common cardiovascular diseases. Magnetic resonance imaging (MRI) and spectroscopy (MRS) techniques have advanced over recent years and offer unique, powerful insights into cardiac anatomic and metabolic changes, respectively, occurring in both nascent and advanced heart disease. Although numerous MRI-based in vivo diagnostics are already used in routine clinical practice and more are anticipated, MRS has been less incorporated into routine clinical practice. Given the ability of H MRS to identify and quantify specific molecules with high sensitivity and specificity, its potential utility should be successfully transition from "bench-to-bedside" is tantalizing. The present review will highlight the development of H MRS techniques for cardiac applications, observations in seminal studies with H MRS, and the prospects and challenges for widespread application in patients with cardiovascular disease.
为了实现个性化医疗对常见心血管疾病产生影响的潜力，检验医学需要持续进步。近年来，磁共振成像（MRI）和光谱学（MRS）技术取得了进展，分别为早期和晚期心脏病中发生的心脏解剖和代谢变化提供了独特而有力的见解。尽管许多基于MRI的体内诊断方法已在常规临床实践中使用，并且预计会有更多方法出现，但MRS较少被纳入常规临床实践。鉴于氢质子磁共振波谱（1H MRS）能够以高灵敏度和特异性识别和定量特定分子，其从“实验室到床边”成功转化的潜在效用令人心动。本综述将重点介绍用于心脏应用的1H MRS技术的发展、1H MRS在开创性研究中的观察结果，以及在心血管疾病患者中广泛应用的前景和挑战。
