Chetverikova L K, Ki'ldivatov I Iu, Inozemtseva L I, Kramskaia T A, Filippov V K, Frolov B A
Vestn Akad Med Nauk SSSR. 1989(11):63-8.
Findings of original research on the factors of nonspecific resistance (interferon formation, antibacterial activity of peritoneal exudate cells, and natural cytotoxicity of splenocytes) and immunity (changes in sub-populational composition of spleen lymphocytes) in different types of influenza in mice are analysed. There was no infection-mediated suppression of the studied reactions, that could have been considered as a cause of death or a basis for immunodeficiency status. The correlation of the level of cerebral lipid peroxidation in mice with severe infection formed the basis for testing the synthetic antioxidant ionol as an anti-influenza agent. A prophylactic effect of ionol toward the development of influenza infection has been obtained. Its possible actions and the feasibility of search for prophylactic and therapeutic preparations among the agents with pathogenetic action is discussed.
分析了关于小鼠不同类型流感中非特异性抗性因素（干扰素形成、腹膜渗出细胞的抗菌活性和脾细胞的自然细胞毒性）以及免疫（脾淋巴细胞亚群组成变化）的原始研究结果。未发现感染介导的对所研究反应的抑制，而这种抑制本可被视为死亡原因或免疫缺陷状态的基础。小鼠严重感染时脑脂质过氧化水平的相关性为测试合成抗氧化剂离子醇作为抗流感药物奠定了基础。已获得离子醇对流感感染发展的预防作用。讨论了其可能的作用以及在具有致病作用的药物中寻找预防和治疗制剂的可行性。
