Chetverikova L K, Inozemtseva L I
Vestn Ross Akad Med Nauk. 1996(3):37-40.
This study has provided evidence for a considerable role of lipid peroxidation in the pathogenesis of murine influenza infection. The virus-induced activation of lipid peroxidation was followed by the enhanced activity of endogenous enzymes of the antioxidative protection system. The preventive effect of an antioxidant and the therapeutical effect of an antihypoxant were recorded in the prevention of murine death due to influenza. The mechanisms of the protective effect of the antihypoxant is due both to its immediate antihypoxant function and its correcting influence on lipid peroxidation.
本研究为脂质过氧化在小鼠流感感染发病机制中发挥的重要作用提供了证据。病毒诱导的脂质过氧化激活之后，抗氧化保护系统的内源性酶活性增强。记录到抗氧化剂的预防作用以及抗缺氧剂对预防小鼠因流感死亡的治疗作用。抗缺氧剂的保护作用机制既归因于其直接的抗缺氧功能，也归因于其对脂质过氧化的纠正影响。
