Zeitlin Ross, Nguyen Harrison P, Rafferty David, Tyring Stephen
University of Florida College of Medicine, 1600 SW Archer Rd., Gainesville, FL 32603, USA.
Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.
J Clin Med. 2015 Apr 24;4(5):822-31. doi: 10.3390/jcm4050822.
Head and neck carcinomas have long been linked to alcohol and tobacco abuse; however, within the last two decades, the human papillomavirus (HPV) has emerged as a third etiology and is specifically associated with head and neck squamous cell carcinomas (HNSCC). In this anatomical region, the oncogenic HPV-16 mediates transformation and immortalization of epithelium, most commonly in the oropharynx. Nevertheless, the recent identification of novel HPV mechanisms thought to be specific to oropharyngeal carcinogenesis has coincided with observations that HPV-associated HNSCC has differing clinical behavior-in terms of natural history, therapeutic response, and prognosis-than HPV-negative head and neck tumors. Taken together with the growing incidence of HPV transmission in younger populations, these discoveries have sparked a rapid expansion in both laboratory and clinical studies on the infection and disease. Herein, we review the clinical characteristics of HPV-associated HNSCC, with particular emphasis on recent advancements in our understanding of the management of this infectious malignancy.
头颈癌长期以来一直与酗酒和吸烟有关；然而，在过去二十年中，人乳头瘤病毒（HPV）已成为第三种病因，并且特别与头颈部鳞状细胞癌（HNSCC）相关。在这个解剖区域，致癌性HPV-16介导上皮细胞的转化和永生化，最常见于口咽。尽管如此，最近发现的被认为是口咽癌发生所特有的新型HPV机制，与此同时观察到HPV相关的HNSCC在自然史、治疗反应和预后方面与HPV阴性的头颈部肿瘤具有不同的临床行为。再加上年轻人群中HPV传播发生率的不断上升，这些发现引发了关于该感染和疾病的实验室和临床研究的迅速扩展。在此，我们综述HPV相关HNSCC的临床特征，特别强调我们对这种传染性恶性肿瘤管理的理解方面的最新进展。
