一种从了哥王根中提取的具有抗病毒活性的新双黄酮。

A new biflavonoid with antiviral activity from the roots of Wikstroemia indica.

作者信息

Huang Wei-Huan, Zhou Guang-Xiong, Wang Guo-Cai, Chung Hau-Yin, Ye Wen-Cai, Li Yao-Lan

机构信息

Biology Program, School of Life Science, The Chinese University of Hong Kong, New Territories, Hong Kong, SAR, China.

出版信息

J Asian Nat Prod Res. 2012;14(4):401-6. doi: 10.1080/10286020.2011.653963.

DOI:10.1080/10286020.2011.653963

PMID:22375879

Abstract

A new biflavonoid, 4'-methoxydaphnodorin E, was isolated from the antiviral fraction of Wikstroemia indica against respiratory syncytial virus (RSV). Its structure was determined on the basis of extensive spectroscopic data including HR-ESI-MS and 2D NMR. The biflavonoid was tested for its in vitro anti-RSV activity with cytopathic effect (CPE) reduction assay, and displayed potent effect with 50% inhibitory concentration (IC₅₀) value of 2.8 μM and selective index (SI) value of 5.4.

摘要

从了哥王抗呼吸道合胞病毒（RSV）的抗病毒活性部位中分离出一种新的双黄酮，4'-甲氧基荛花素E。基于包括高分辨电喷雾电离质谱（HR-ESI-MS）和二维核磁共振（2D NMR）在内的大量光谱数据确定了其结构。采用细胞病变效应（CPE）减少试验对该双黄酮的体外抗RSV活性进行了测试，其表现出强效作用，50%抑制浓度（IC₅₀）值为2.8 μM，选择性指数（SI）值为5.4。