Zhang Yumin, Zhang Siwen, Wang Guixia
Department of Endocrinology and Metabolism, the First Hospital of Jilin University, Changchun, 130021, China.
Department of Endocrinology and Metabolism, the First Hospital of Jilin University, Changchun, 130021, China.
J Diabetes Complications. 2015 Nov-Dec;29(8):1345-51. doi: 10.1016/j.jdiacomp.2015.06.016. Epub 2015 Jul 9.
Diabetic kidney disease (DKD) is generally characterized by increasing albuminuria in diabetic patients; however, few biomarkers are available to facilitate early diagnosis of this disease. The application of metabolomics has shown promises addressing this need. In this review, we conducted a search about metabolomic biomarkers in DKD patients through MEDLINE, EMBASE, and Cochrane Database up to the end of March, 2015. 12 eligible studies were selected and evaluated subsequently through the use of QUADOMICS, a quality assessment tool. 7 of the 12 included studies were classified as 'high quality'. We also recorded specific study characteristics including participants' characteristics, metabolomic techniques, sample types, and significantly altered metabolites between DKD and control groups. Products of lipid metabolisms including esterified and non-esterified fatty acids, carnitines, phospholipids and metabolites involved in branch-chained amino acids and aromatic amino acids metabolisms were frequently affected biomarkers of DKD. Other differential metabolites were also found, while some of their associations with DKD were unclear. Further more studies are required to test these findings in larger, diverse ethnic populations with elaborate study designs, and finally we could translate them into the benefits of DKD patients.
糖尿病肾病（DKD）通常表现为糖尿病患者蛋白尿增加；然而，几乎没有生物标志物可用于促进该疾病的早期诊断。代谢组学的应用已显示出满足这一需求的前景。在本综述中，我们通过检索MEDLINE、EMBASE和Cochrane数据库，对截至2015年3月底的DKD患者代谢组学生物标志物进行了研究。随后，通过使用质量评估工具QUADOMICS，选择并评估了12项符合条件的研究。12项纳入研究中有7项被归类为“高质量”。我们还记录了具体的研究特征，包括参与者特征、代谢组学技术、样本类型以及DKD组和对照组之间显著改变的代谢物。脂质代谢产物，包括酯化和非酯化脂肪酸、肉碱、磷脂以及参与支链氨基酸和芳香族氨基酸代谢的代谢物，是DKD常见的受影响生物标志物。还发现了其他差异代谢物，但其与DKD的一些关联尚不清楚。需要进一步开展更多研究，在更大规模、种族多样的人群中采用精心设计的研究方案来验证这些发现，最终将其转化为DKD患者的益处。
