Fukuhara Takahiro, Matsuda Eriko, Izawa Shoichiro, Fujiwara Kazunori, Kitano Hiroya
Department of Otolaryngology-Head and Neck Surgery, Tottori University Faculty of Medicine, 36-1 Nishi-cho, Yonago, Tottori 683-8504, Japan.
Endocrinology and Metabolism, Department of Molecular Medicine and Therapeutics, Tottori University Faculty of Medicine, 36-1 Nishi-cho, Yonago, Tottori 683-8504, Japan.
J Thyroid Res. 2015;2015:164548. doi: 10.1155/2015/164548. Epub 2015 Jul 16.
The aims of this study were to evaluate the utility of shear wave elastography (SWE) using acoustic radiation force impulse (ARFI) for diagnosing chronic autoimmune thyroiditis (CAT) and to verify the effect of fibrotic thyroid tissue on shear wave velocity (SWV). The subjects were 229 patients with 253 normal thyroid lobes (controls) and 150 CAT lobes. The SWV for CAT (2.47 ± 0.57 m/s) was significantly higher than that for controls (1.59 ± 0.41 m/s) (P < 0.001). The area under the receiver operating characteristics (ROC) curve for CAT was 0.899, and the SWV cut-off value was 1.96 m/s. The sensitivity, specificity, and diagnostic accuracy were 87.4%, 78.7%, and 85.1%, respectively. Levels of anti-thyroperoxidase antibodies and thyroid isthmus thickness were correlated with tissue stiffness in CAT. However, there was no correlation between levels of anti-thyroglobulin antibodies and tissue stiffness. Quantitative SWE is useful for diagnosing CAT, and it is possible that SWE can be used to evaluate the degree of fibrosis in patients with CAT.
本研究的目的是评估使用声辐射力脉冲（ARFI）的剪切波弹性成像（SWE）在诊断慢性自身免疫性甲状腺炎（CAT）中的效用，并验证甲状腺纤维化组织对剪切波速度（SWV）的影响。研究对象为229例患者，包括253个正常甲状腺叶（对照组）和150个CAT叶。CAT组的SWV（2.47±0.57 m/s）显著高于对照组（1.59±0.41 m/s）（P<0.001）。CAT的受试者操作特征（ROC）曲线下面积为0.899，SWV临界值为1.96 m/s。敏感性、特异性和诊断准确性分别为87.4%、78.7%和85.1%。抗甲状腺过氧化物酶抗体水平和甲状腺峡部厚度与CAT中的组织硬度相关。然而，抗甲状腺球蛋白抗体水平与组织硬度之间无相关性。定量SWE对CAT诊断有用，并且SWE有可能用于评估CAT患者的纤维化程度。
