工作中的社会心理因素与炎症标志物：系统评价和荟萃分析方案。
Psychosocial factors at work and inflammatory markers: protocol for a systematic review and meta-analysis.
机构信息
Department of Public Health, Kitasato University School of Medicine, Sagamihara, Japan.
Department of Mental Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
出版信息
BMJ Open. 2018 Aug 29;8(8):e022612. doi: 10.1136/bmjopen-2018-022612.
INTRODUCTION
Chronic inflammation may be a mediator for the development of cardiovascular disease (CVD), metabolic diseases and psychotic and neurodegenerative disorders. Meta-analytic associations between work-related psychosocial factors and inflammatory markers have shown that work-related psychosocial factors could affect the flexibility and balance of the immune system. However, few systematic reviews or meta-analyses have investigated the association between work-related psychosocial factors and inflammatory markers. Based on prospective studies, the present investigation will conduct a comprehensive systematic review and meta-analysis of the association between work-related psychosocial factors and inflammatory markers.
METHODS AND ANALYSIS
The systematic review and meta-analysis will include published studies identified from electronic databases (PubMed, EMBASE, PsycINFO, PsycARTICLES, Web of Science and Japan Medical Abstracts Society) according to recommendations of the Meta-analysis of Observational Studies in Epidemiology guideline. Inclusion criteria are studies that: examined associations between work-related psychosocial factors and increased inflammatory markers; used longitudinal or prospective cohort designs; were conducted among workers; provided sufficient data for calculating ORs or relative risk with 95% CIs; were published as original articles in English or Japanese; and were published up to the end of 2017. Study selection, data extraction, quality assessment and statistical syntheses will be conducted by 14 investigators. Any inconsistencies or disagreements will be resolved through discussion. The quality of studies will be evaluated using the Risk of Bias Assessment Tool for Non-randomized Studies.
ETHICS AND DISSEMINATION
The investigation study will be based on published studies, so ethics approval is not required. The results of this study will be submitted for publication in a scientific peer-reviewed journal. The findings may be useful for assessing risk factors for increased inflammatory markers in the workplace and determining future approaches for preventing CVD, metabolic diseases and psychotic and neurodegenerative disorders.
PROSPERO REGISTRATION NUMBER
CRD42018081553.
简介
慢性炎症可能是心血管疾病 (CVD)、代谢疾病以及精神和神经退行性疾病发展的一个中介。工作相关心理社会因素与炎症标志物之间的荟萃分析关联表明，工作相关心理社会因素可能会影响免疫系统的灵活性和平衡。然而，很少有系统评价或荟萃分析调查了工作相关心理社会因素与炎症标志物之间的关联。基于前瞻性研究，本研究将对工作相关心理社会因素与炎症标志物之间的关联进行全面的系统综述和荟萃分析。
方法和分析
系统综述和荟萃分析将包括根据《观察性研究荟萃分析流行病学指南》的建议，从电子数据库（PubMed、EMBASE、PsycINFO、PsycARTICLES、Web of Science 和日本医学文摘协会）中确定的已发表研究。纳入标准为：研究工作相关心理社会因素与炎症标志物升高之间的关系；使用纵向或前瞻性队列设计；在工人中进行；提供了用于计算 OR 或 95%CI 相对风险的足够数据；以英文或日文发表的原始文章；并于 2017 年底前发表。14 名调查员将进行研究选择、数据提取、质量评估和统计综合。任何不一致或分歧将通过讨论解决。研究质量将使用非随机研究风险偏倚评估工具进行评估。
伦理和传播
该研究将基于已发表的研究，因此不需要伦理批准。本研究的结果将提交给科学同行评审期刊发表。研究结果可能有助于评估工作场所炎症标志物升高的危险因素，并确定预防 CVD、代谢疾病以及精神和神经退行性疾病的未来方法。
PROSPERO 注册号：CRD42018081553。
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