Schneider J, Ruiz-Torres A
Aktuelle Gerontol. 1978 Mar;8(3):159-65.
It could be demonstrated that there was an age-dependent increase of digitalisintoxications in correlation with digitalisconcentrations in blood. This phenomenon can be explained with the frequently observed underweight in the senium. Some patients older than 70 years showed symptoms of intoxication in spite of a normal digitalisconcentration in serum. But the presented results did not demonstrate a significant difference between young and old patients concerning the sensitivity against digitalis. Therefore it is necessary to consider the bodyweight for digitalis therapy in older patients.
可以证明,洋地黄中毒与血液中洋地黄浓度相关,且存在年龄依赖性增加。这种现象可以用老年时经常观察到的体重不足来解释。一些70岁以上的患者尽管血清洋地黄浓度正常,但仍出现中毒症状。但所呈现的结果并未显示年轻患者和老年患者对洋地黄的敏感性存在显著差异。因此,在老年患者的洋地黄治疗中,有必要考虑体重因素。