Xu Dong, You Xin, Wang Zhengang, Zeng Qingyu, Xu Jianhua, Jiang Lindi, Gong Lu, Wu Fengqi, Gu Jieruo, Tao Yi, Chen Jinwei, Zhao Jiuliang, Li Mengtao, Zhao Yan, Zeng Xiaofeng
Department of Rheumatology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences; Key Laboratory of Rheumatology and Clinical Immunology, Ministry of Education; No.1 Shuaifuyuan, Beijing, 100730, China.
Department of Rheumatology, Beijing Tongren Hospital Affiliated to Capital Medical University, NO 1, Dong Jiao Min Xiang, Eastern District, Beijing, 100730, China.
PLoS One. 2015 Aug 17;10(8):e0134451. doi: 10.1371/journal.pone.0134451. eCollection 2015.
Our study aimed to investigate the effect of cigarette smoking on the clinical phenotype of patients registered in the Chinese Systemic Lupus Erythematosus (SLE) Treatment and Research (CSTAR) group registry database, the first online registry of Chinese patients with SLE.
A prospective cross-sectional study of Chinese SLE patients was conducted using the CSTAR. Our case-control analysis was performed on age- and gender-matched subjects to explore the potential effect of cigarette smoking on the clinical manifestation of SLE.
Smokers comprised 8.9% (65/730) of patients, and the ratio of females/males was 19/46. Thirty-nine patients were current smokers, and 26 were ex-smokers. Data showed significant differences between smokers and nonsmokers in the following areas: nephropathy (58.5% vs. 39.2%; p = 0.003), microscopic hematuria (30.8% vs. 19.1%; p = 0.025), proteinuria (53.8% vs. 34.4%; p = 0.002), and SLE Disease Activity Index(DAI) scores (12.38±8.95 vs. 9.83±6.81; p = 0.028). After adjusting for age and gender, significant differences between smokers and nonsmokers were found with photosensitivity (35.9% vs. 18%; p = 0.006), nephropathy (59.4% vs. 39.8%; p = 0.011), and proteinuria (54.7% vs. 35.2%). Although smokers tended to have greater disease severity compared with nonsmokers (SLEDAI scores: 12.58±8.89 vs.10.5±7.09), the difference was not significant (p = 0.081).
Cigarette smoking triggers the development and exacerbation of SLE, especially with respect to renal involvement. Chinese smokers with SLE should be advised to discontinue cigarette use.
我们的研究旨在调查吸烟对中国系统性红斑狼疮（SLE）治疗与研究（CSTAR）组登记数据库（首个中国SLE患者在线登记库）中登记患者临床表型的影响。
使用CSTAR对中国SLE患者进行前瞻性横断面研究。我们对年龄和性别匹配的受试者进行病例对照分析，以探讨吸烟对SLE临床表现的潜在影响。
吸烟者占患者的8.9%（65/730），女性/男性比例为19/46。39例为当前吸烟者，26例为既往吸烟者。数据显示吸烟者和非吸烟者在以下方面存在显著差异：肾病（58.5%对39.2%；p = 0.003）、镜下血尿（30.8%对19.1%；p = 0.025）、蛋白尿（53.8%对34.4%；p = 0.002）以及SLE疾病活动指数（DAI）评分（12.38±8.95对9.83±6.81；p = 0.028）。在调整年龄和性别后，吸烟者和非吸烟者在光敏性（35.9%对18%；p = 0.006）、肾病（59.4%对39.8%；p = 0.011）和蛋白尿（54.7%对35.2%）方面存在显著差异。尽管吸烟者与非吸烟者相比疾病严重程度往往更高（SLEDAI评分：12.58±8.89对10.5±7.09），但差异不显著（p = 0.081）。
吸烟会引发SLE的发生和加重，尤其是在肾脏受累方面。应建议患有SLE的中国吸烟者戒烟。
