Division of Rheumatology, Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland.
Clin Rheumatol. 2013 Aug;32(8):1219-22. doi: 10.1007/s10067-013-2224-4. Epub 2013 Mar 21.
This study aims to study the association of smoking with the development of systemic lupus erythematosus (SLE). The study included 223 SLE patients (92 % women, mean age 47 years) and 1,538 population controls of similar age and socioeconomic status living in the metropolitan area of Finland. The history of smoking in patients and controls was obtained by personal interview. The prevalence of current and past smoking was more common in patients with SLE than in controls. In women with a history of daily smoking for more than 1 year, the odds ratio (OR) for SLE was 1.45 (95 % CI 1.07-1.97), in current daily smokers as compared to never smokers, the OR was 1.55 (1.00-2.40), and in ex-smokers versus never smokers 1.80 (1.15-2.83). The number of men with SLE, who had smoked more than 100 cigarettes during their lifetime was higher than in male controls (p = 0.026). A history of smoking is significantly though modestly associated with the development of SLE.
本研究旨在探讨吸烟与系统性红斑狼疮（SLE）发展之间的关联。研究纳入了 223 名 SLE 患者（92%为女性，平均年龄 47 岁）和 1538 名居住在芬兰大都市地区、年龄和社会经济地位相似的人群对照。通过个人访谈获得了患者和对照者的吸烟史。与对照组相比，SLE 患者中当前和既往吸烟的患病率更高。在女性中，每日吸烟超过 1 年的患者中，SLE 的比值比（OR）为 1.45（95%CI 1.07-1.97），与从不吸烟者相比，当前每日吸烟者的 OR 为 1.55（1.00-2.40），与从不吸烟者相比，既往吸烟者的 OR 为 1.80（1.15-2.83）。一生中吸烟超过 100 支的 SLE 男性患者人数高于男性对照组（p=0.026）。吸烟史与 SLE 的发生显著相关，但相关性较弱。
