Wang Rong, Wang Yu, Li Dazhou, Yu Li, Liu Gang, Ma Jun, Wang Wen
Department of Gastroenterology, Fuzhou General Hospital, No.156 Xi'erhuan North Rd, Fuzhou, 350025, Fujian, China.
Department of Gastroenterology, Dongfang Hospital, Xiamen University, Fuzhou, 350025, Fujian, China.
Surg Endosc. 2016 Apr;30(4):1530-3. doi: 10.1007/s00464-015-4367-7. Epub 2015 Aug 19.
Endoscopic surgery has been a novel treatment for colon polyps or even early colorectal cancer. However, the exact re-inspection after colonic polypectomy to detect the scar from polyp removal was difficult to be performed. In our previous study, colon cancer tattooed with carbon nanoparticles was easily found during surgery. We speculated that carbon nanoparticles could be used in exact re-inspection after colonic polypectomy.
To evaluate the efficiency of carbon nanoparticles for re-inspection after colonic polypectomy.
Twenty-four patients with precancerous lesion or early colorectal cancer that underwent colonoscopic polypectomy between October 2012 and December 2013 were enrolled in the study. Participants were divided into two groups. Group A patients were injected with carbon nanoparticles beneath the lesion sites 3 cm. Group B patients were not treated with nanoparticles. All patients underwent quarterly colonoscopies. Once the colonoscope was withdrawn from the site last time record, the time spent searching for lesions was recorded.
There were no significant differences between general conditions or lesion pathology between the groups. The time spent searching for lesions in Group B was much longer than that in Group A (13.67 ± 8.07 vs. 1.21 ± 0.39 min, P < 0.001). Carbon nanoparticles marked lesions for 12 months in some patients, and no adverse reactions were reported.
It was a small sample study.
Tattooing lesions using carbon nanoparticles suspensions is safe. The durability of dye enables lesions to be re-checked by colonoscopy or laparoscopy for up to 1 year.
内镜手术已成为治疗结肠息肉甚至早期结直肠癌的一种新方法。然而，结肠息肉切除术后进行精确复查以检测息肉切除后的瘢痕却很难实现。在我们之前的研究中，术中很容易发现用碳纳米颗粒标记的结肠癌。我们推测碳纳米颗粒可用于结肠息肉切除术后的精确复查。
评估碳纳米颗粒在结肠息肉切除术后复查中的有效性。
选取2012年10月至2013年12月期间接受结肠镜息肉切除术的24例癌前病变或早期结直肠癌患者纳入研究。将参与者分为两组。A组患者在病变部位下方3 cm处注射碳纳米颗粒。B组患者未接受纳米颗粒治疗。所有患者每季度接受一次结肠镜检查。每次结肠镜从上次记录的部位撤出后，记录寻找病变所花费的时间。
两组患者的一般情况或病变病理无显著差异。B组寻找病变所花费的时间比A组长得多（13.67±8.07 vs. 1.21±0.39分钟，P<0.001）。碳纳米颗粒在一些患者中标记病变长达12个月，且未报告不良反应。
这是一项小样本研究。
使用碳纳米颗粒混悬液标记病变是安全的。染料的持久性使病变能够通过结肠镜检查或腹腔镜检查进行长达1年的复查。
