Khandpur Sujay, Jain Naresh, Singla Shweta, Chatterjee Priti, Behari Madhuri
Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India.
Department of Neurology, All India Institute of Medical Sciences, New Delhi, India.
Indian J Dermatol. 2015 Jul-Aug;60(4):406-9. doi: 10.4103/0019-5154.160498.
D-penicillamine interferes with elastin and collagen metabolism and produces several cutaneous and multi-systemic side-effects. We present two cases of Wilson's disease who on long-term penicillamine therapy developed drug-induced degenerative dermopathy manifesting as skin fragility over pressure sites and cutis laxa-like changes.