Harden A, Adams G G, Taylor D S
Department of Clinical Neurophysiology, Hospital for Sick Children, London.
Arch Dis Child. 1989 Jul;64(7):1080-7. doi: 10.1136/adc.64.7.1080.
The electroretinogram, findings, in response to a flash stimulus, was recorded from a skin electrode placed on the bridge of the nose in 4465 infants and children seen over a 10 year period. The electroretinogram was combined with a flash visual evoked potential. From this total, the electroretinographic findings in 240 patients, aged 1 day to 17 years, without suspected retinal pathology and with a normal visual evoked potential, were used as controls and normal electroretinographic parameters of different age groups defined. There were 332 patients who showed an absent or very reduced amplitude electroretinogram. They were divided into primarily ocular disorders (n = 195), neurodegenerative disorders (n = 94), and various syndromes (n = 43). Fundus examination did not always show any obvious abnormalities. The use of this simple and reliable technique for recording the electroretinogram made it possible to include this investigation as a routine procedure without the need for sedation in infants and uncooperative children. Electroretinographic studies, especially when combined with visual evoked potentials, and in some cases electroencephalography, may aid diagnosis in a wide variety of paediatric conditions, many of which have genetic implications.
在10年期间对4465名婴幼儿及儿童进行了研究，通过放置在鼻梁上的皮肤电极记录了他们对闪光刺激的视网膜电图结果。视网膜电图与闪光视觉诱发电位相结合。从这些研究对象中，选取了240名年龄在1天至17岁之间、无视网膜病变可疑且视觉诱发电位正常的患者作为对照组，并确定了不同年龄组的正常视网膜电图参数。有332名患者的视网膜电图振幅缺失或显著降低。他们被分为原发性眼部疾病组（n = 195）、神经退行性疾病组（n = 94）和各种综合征组（n = 43）。眼底检查并不总是显示出明显异常。使用这种简单可靠的视网膜电图记录技术，使得在婴儿和不合作儿童中无需镇静即可将此项检查作为常规程序。视网膜电图研究，尤其是与视觉诱发电位相结合，以及在某些情况下与脑电图相结合，可能有助于诊断多种儿科疾病，其中许多疾病具有遗传意义。
