Scalea Joseph R, Bromberg Jonathan, Bartlett Stephen T, Scalea Thomas M
Division of Transplantation, Department of Surgery, University of Wisconsin, Madison, WI.
Department of Surgery, University of Maryland, Baltimore, MD.
J Crit Care. 2015 Dec;30(6):1344-8. doi: 10.1016/j.jcrc.2015.07.024. Epub 2015 Jul 29.
Most human diseases, including trauma, atherosclerosis, and malignancy, can be characterized by either an overexuberant inflammatory response or an inadequate immunologic response. As our understanding of the mechanisms underlying these inflammatory aberrations improves, so should our approach to the patient. The development of novel technologies capable of exploiting inflammatory mediators will undoubtedly play a role in future patient-directed therapies. Trauma surgeons are uniquely positioned to usher in a new era of patient diagnostics and patient-directed therapies based on an understanding of the immune system's response to stimuli. These improvements are likely to affect not only trauma care but all aspects of medicine.
大多数人类疾病，包括创伤、动脉粥样硬化和恶性肿瘤，其特征要么是炎症反应过度，要么是免疫反应不足。随着我们对这些炎症异常背后机制的理解不断加深，我们对患者的治疗方法也应如此。能够利用炎症介质的新技术的发展无疑将在未来以患者为导向的治疗中发挥作用。创伤外科医生处于独特的地位，基于对免疫系统对刺激的反应的理解，开创患者诊断和以患者为导向的治疗的新时代。这些进步可能不仅会影响创伤护理，还会影响医学的各个方面。
