聚合物/氧化铁纳米颗粒复合材料——一种直接且可扩展的合成方法。

Polymer/Iron Oxide Nanoparticle Composites--A Straight Forward and Scalable Synthesis Approach.

作者信息

Sommertune Jens, Sugunan Abhilash, Ahniyaz Anwar, Bejhed Rebecca Stjernberg, Sarwe Anna, Johansson Christer, Balceris Christoph, Ludwig Frank, Posth Oliver, Fornara Andrea

机构信息

SP, Technical Research Institute of Sweden, Box 5607, SE-114 86 Stockholm, Sweden.

Department of Engineering Sciences, Solid State Physics, Uppsala University, SE-751 21 Uppsala, Sweden.

出版信息

Int J Mol Sci. 2015 Aug 20;16(8):19752-68. doi: 10.3390/ijms160819752.

DOI:10.3390/ijms160819752

PMID:26307966

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4581323/

Abstract

Magnetic nanoparticle systems can be divided into single-core nanoparticles (with only one magnetic core per particle) and magnetic multi-core nanoparticles (with several magnetic cores per particle). Here, we report multi-core nanoparticle synthesis based on a controlled precipitation process within a well-defined oil in water emulsion to trap the superparamagnetic iron oxide nanoparticles (SPION) in a range of polymer matrices of choice, such as poly(styrene), poly(lactid acid), poly(methyl methacrylate), and poly(caprolactone). Multi-core particles were obtained within the Z-average size range of 130 to 340 nm. With the aim to combine the fast room temperature magnetic relaxation of small individual cores with high magnetization of the ensemble of SPIONs, we used small (<10 nm) core nanoparticles. The performed synthesis is highly flexible with respect to the choice of polymer and SPION loading and gives rise to multi-core particles with interesting magnetic properties and magnetic resonance imaging (MRI) contrast efficacy.

摘要

磁性纳米粒子系统可分为单核纳米粒子（每个粒子仅含有一个磁芯）和磁性多核纳米粒子（每个粒子含有多个磁芯）。在此，我们报告了基于在明确的水包油乳液中进行受控沉淀过程的多核纳米粒子合成方法，以将超顺磁性氧化铁纳米粒子（SPION）捕获在一系列所选的聚合物基质中，如聚苯乙烯、聚乳酸、聚甲基丙烯酸甲酯和聚己内酯。获得的多核粒子的Z平均尺寸范围为130至340纳米。为了将小的单个磁芯在室温下的快速磁弛豫与SPION集合体的高磁化强度相结合，我们使用了小尺寸（<10纳米）的磁芯纳米粒子。所进行的合成在聚合物选择和SPION负载方面具有高度灵活性，并产生了具有有趣磁性和磁共振成像（MRI）造影效果的多核粒子。