Volkov G L, Gula N M, Govseieva N M, Artemenko I P, Perederiĭ O F, Khomutovs'kiĭ O A
Ukr Biokhim Zh (1978). 1989 Nov-Dec;61(6):69-75.
The methods of isotopic and fluorescent labels have shown that interaction of cells of neuroblastoma S 1300 N 18 with small one-layer neutral liposomes prepared of the egg phosphatidyl choline with the addition of different amounts of cholesterol is realized by two mechanisms: the transmembrane transfer of cholesterol by the concentration gradient and membrane lipid metabolism proper, the ratios of cholesterol phospholipids in the biological and artificial membranes being equal. A dependence is established of the neuroblastoma cell viability on the activity of the cholesterol membrane metabolism. A problem on the mechanism which causes the death of cells during the interaction with phosphatidyl-cholesterol liposomes is under discussion.
同位素标记法和荧光标记法表明，神经母细胞瘤S 1300 N 18细胞与由鸡蛋卵磷脂制备并添加不同量胆固醇的单层中性小脂质体之间的相互作用是通过两种机制实现的：胆固醇通过浓度梯度进行跨膜转运以及适当的膜脂质代谢，生物膜和人工膜中胆固醇与磷脂的比例相等。已确定神经母细胞瘤细胞活力与胆固醇膜代谢活性之间的依赖关系。关于细胞在与磷脂酰胆固醇脂质体相互作用过程中死亡的机制问题正在讨论中。
