Forwood James M, Bubner Erin J, Landos Matt, D'Antignana Trent, Deveney Marty R
Lincoln Marine Science Centre, School of Biological Sciences, Flinders University, Port Lincoln, SA, Australia.
Future Fisheries Veterinary Services Pty Ltd, East Ballina, NSW, 2478, Australia.
Fish Physiol Biochem. 2016 Feb;42(1):103-9. doi: 10.1007/s10695-015-0121-2. Epub 2015 Aug 28.
Regulatory approval is being sought to use praziquantel (PZQ) to treat flukes infecting yellowtail kingfish (YTK), but accurate safety data were not available. We investigated the effect of increased doses or prolonged exposure of orally administered PZQ on YTK by assessing changes in haematological and biochemical characteristics, and mortality. Fish were intubated daily for 3 days with 0, 100, 300 and 500 mg PZQ kg(-1) BW day(-1) or once daily for 9 days at 0 and 100 mg PZQ kg(-1) BW day(-1). Blood was taken 24 h after the cessation of treatment. There was no significant difference between any of the haematological or biochemical indices in YTK treated with PZQ and controls, indicating that PZQ is safe for use at 100 mg PZQ kg(-1) BW day(-1) in YTK and that exposure to high doses or prolonged duration does not have negative effects on the YTK haematological or biochemical parameters we measured.
正在寻求监管批准以使用吡喹酮（PZQ）治疗感染黄尾𫚕（YTK）的吸虫，但尚无准确的安全数据。我们通过评估血液学和生化特征的变化以及死亡率，研究了口服PZQ剂量增加或暴露时间延长对黄尾𫚕的影响。鱼每天插管3天，分别给予0、100、300和500毫克PZQ/千克体重/天，或每天一次，连续9天给予0和100毫克PZQ/千克体重/天。治疗停止24小时后采集血液。用PZQ处理的黄尾𫚕的任何血液学或生化指标与对照组之间均无显著差异，这表明PZQ以100毫克PZQ/千克体重/天的剂量用于黄尾𫚕是安全的，并且高剂量暴露或长时间暴露对我们测量的黄尾𫚕血液学或生化参数没有负面影响。
