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吡喹酮对鱼类和浮游甲壳类动物的急性毒性

Acute toxicity of praziquantel to fish and planktonic crustacean .

作者信息

Zuskova Eliska, Piackova Veronika, Valentova Olga, Zalohova Klara, Velisek Josef

机构信息

South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses, Faculty of Fisheries and Protection of Waters, University of South Bohemia in Ceske Budejovice, Ceske Budejovice, Czech Republic.

出版信息

Vet Med (Praha). 2022 Oct 24;67(11):579-584. doi: 10.17221/7/2022-VETMED. eCollection 2022 Oct.

DOI:10.17221/7/2022-VETMED
PMID:38623477
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11016302/
Abstract

This study evaluated the toxicity of the pyrazino isoquinoline anthelmintic praziquantel (PZQ) to the  zebrafish and water flea. The estimated 24 h and 96 h LC50 of PZQ to the zebrafish was 39.9 mg/l and 30.4 mg/l, respectively. The highest 24 h and 96 h non-lethal concentration (LC0) was 21.7 mg/l and 21.2 mg/l, respectively. The mobility inhibition test of the juvenile revealed a 48 h EC50 of 42.7 mg/l.

摘要

本研究评估了吡嗪异喹啉驱虫药吡喹酮（PZQ）对斑马鱼和水蚤的毒性。PZQ对斑马鱼的24小时和96小时半数致死浓度（LC50）估计分别为39.9毫克/升和30.4毫克/升。24小时和96小时最高非致死浓度（LC0）分别为21.7毫克/升和21.2毫克/升。幼鱼的运动抑制试验显示48小时半数效应浓度（EC50）为42.7毫克/升。