Carlson Paul E, Bourgis Alexandra E T, Hagan Ada K, Hanna Philip C
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48104, USA.
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48104, USA
Pathog Dis. 2015 Nov;73(8):ftv061. doi: 10.1093/femspd/ftv061. Epub 2015 Aug 26.
During the late stages of systemic anthrax, Bacillus anthracis grows rapidly in the host bloodstream. To identify potential genes necessary for this observed rapid growth, we defined the transcriptional profile of B. anthracis during in vitro growth in bovine blood. Genome-wide transcriptome analysis indicated that B. anthracis undergoes significant changes in its transcriptome profile during growth in blood, including the differential regulation of genes associated both with metabolism and known virulence factors. Collectively, these data provide a framework for future studies identifying specific B. anthracis factors required for growth in the mammalian bloodstream.
在系统性炭疽的晚期阶段，炭疽芽孢杆菌在宿主体内的血液中迅速生长。为了确定这种观察到的快速生长所必需的潜在基因，我们定义了炭疽芽孢杆菌在牛血中体外生长期间的转录谱。全基因组转录组分析表明，炭疽芽孢杆菌在血液中生长期间其转录组谱发生了显著变化，包括与代谢和已知毒力因子相关的基因的差异调控。总的来说，这些数据为未来研究确定炭疽芽孢杆菌在哺乳动物血液中生长所需的特定因子提供了一个框架。
