Gause Trent M, Kling Russell E, Sivak Wesley N, Marra Kacey G, Rubin J Peter, Kokai Lauren E
Department of Plastic Surgery; University of Pittsburgh School of Medicine ; Pittsburgh, PA USA.
Adipocyte. 2014 Dec 10;3(4):273-9. doi: 10.4161/21623945.2014.957987. eCollection 2014 Oct-Dec.
Fat grafting popularity continues to rise among plastic surgeons. As a soft tissue filler, adipose tissue had many desirable attributes: it is easy to obtain, autologous, and may reintegrate into recipient sites. However, fat grafting is clinically plagued by unpredictable resorption rates, thus there is much interest in optimizing the procedure of fat grafting for consistent graft volumes. Fat harvesting, a part of fat transfer surgery, involves the removal of adipose tissue from the donor site. Different harvest procedures, such as whole fat excision or liposuction cannulas, result in a range of fat particle volumes, which may play a role in the cellular stability of grafts. The ideal harvesting technique and fat particle diameter is not currently known. This study aims to review the literature on the impact of fat particle size and clinical fat grafting outcomes, to present overarching conclusions, and to provide future directions for study. Current evidence supports excisional methods and larger bore cannulas to minimize cellular damage, preserve the native architecture, and maximize the number of cells within fat particles.
脂肪移植在整形外科医生中越来越受欢迎。作为一种软组织填充剂，脂肪组织具有许多理想的特性：易于获取、自体性且可重新整合到受体部位。然而，脂肪移植在临床上受到不可预测的吸收率的困扰，因此人们对优化脂肪移植程序以获得一致的移植体积非常感兴趣。脂肪采集是脂肪移植手术的一部分，涉及从供体部位去除脂肪组织。不同的采集程序，如全脂肪切除或抽脂套管，会导致一系列脂肪颗粒体积，这可能对移植组织的细胞稳定性产生影响。目前尚不清楚理想的采集技术和脂肪颗粒直径。本研究旨在回顾关于脂肪颗粒大小对临床脂肪移植结果影响的文献，得出总体结论，并为未来的研究提供方向。目前的证据支持切除方法和较大口径的套管，以尽量减少细胞损伤，保留天然结构，并使脂肪颗粒内的细胞数量最大化。
